Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain

Infection and Immunity
A MullickP Gros

Abstract

Experimental infection of inbred mouse strains with Candida albicans provides a good model system to identify host genetic determinants that regulate onset of, response to, and ultimate outcome of disseminated candidiasis. The A/J mouse strain is exquisitely sensitive to infection with C. albicans, while the C57BL/6J strain is relatively resistant, as measured by survival following intravenous injection of Candida blastospores. This differential susceptibility is caused by an A/J-specific loss-of-function mutation in the C5 component of the complement pathway. C5 plays several critical roles in host response to infection, including target lysis and phagocyte recruitment. Therefore, to determine which of its functions were required for host resistance to candidiasis, a detailed comparative analysis of pathophysiology and host response to acute C. albicans infection was conducted in A/J and C57BL/6J mice. C5-sufficient C57BL/6J mice were found to succumb late in infection due to severe kidney pathology, typified by fungal replication and robust neutrophil-based inflammatory response associated with extensive tissue damage. In contrast, A/J mice were moribund within 24 h postinfection but displayed little if any kidney damage desp...Continue Reading

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D E Chenoweth, T E Hugli
Nov 8, 1979·Nature·Y M Ooi, H R Colten
Sep 1, 1991·Immunology Today·M M Frank, L F Fries
Oct 1, 1986·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·F L LyonJ E Domer
Jan 1, 1967·The Journal of Experimental Medicine·U R Nilsson, H J Müller-Eberhard
Dec 1, 1982·Infection and Immunity·R F HectorE W Carrow
Aug 1, 1980·Infection and Immunity·J C RhodesW J Urba
Jun 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R P Wenzel
Jan 1, 1994·Annual Review of Immunology·C Gerard, N P Gerard
Jun 1, 1993·Immunology and Cell Biology·R B AshmanJ M Papadimitriou
Apr 1, 1996·The Journal of Trauma·R M SherryJ T DiPiro
Jan 1, 1996·Clinical Microbiology Reviews·T R Kozel
Nov 22, 1997·European Journal of Immunology·J J CampbellE C Butcher
Jan 7, 1998·The Journal of Cell Biology·E F FoxmanE C Butcher
Jul 7, 1998·The Journal of Experimental Medicine·J A GonzaloJ C Gutierrez-Ramos
Aug 28, 1998·Research in Immunology·R B Ashman
Jan 8, 1999·Journal of Medical Microbiology·M D WillcoxD W Harty
Aug 25, 1999·Current Opinion in Microbiology·L Romani
Nov 7, 1999·Chemical Immunology·L GuB J Rollins
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M BhatiaM L Steer
May 25, 2001·Journal of the American Society of Nephrology : JASN·Edgar A JaimesLeopoldo Raij
Dec 20, 2002·Nature·Jonathan Cohen
May 1, 1963·Genetics·L A HERZENBERGL T ROSENBERG
Dec 9, 2003·Nature Reviews. Immunology·Luigina Romani
Jan 13, 2004·Nature Medicine·Ji-Jing YanDong-Keun Song
Mar 26, 2004·Nature Reviews. Immunology·Peter A Ward
Sep 17, 2004·Genes and Immunity·A TuiteP Gros
Apr 1, 1971·Infection and Immunity·R Morelli, L T Rosenberg

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Citations

Jul 6, 2010·Nature Medicine·Hugo WurteleMartine Raymond
Jul 25, 2006·Infection and Immunity·Alaka MullickPhilippe Gros
Jul 8, 2009·Infection and Immunity·S Vicky TsoniGordon D Brown
Jun 25, 2008·Infection and Immunity·María de la Cruz Domínguez-PunaroMarcelo Gottschalk
Jan 19, 2012·Infection and Immunity·Shih-Chin ChengMihai G Netea
Oct 24, 2007·Annual Review of Immunology·S M VidalP Gros
May 13, 2006·American Journal of Respiratory Cell and Molecular Biology·Jamie H Rosenblum LichtensteinJoseph D Brain
Dec 30, 2011·PLoS Neglected Tropical Diseases·Ruben Ramirez-AquinoIrma Aguilar-Delfin
May 3, 2011·PloS One·Irena RadovanovicPhilippe Gros
Oct 10, 2009·PLoS Pathogens·Christopher AskewMalcolm Whiteway
Jul 16, 2014·Medical Mycology·Michail S Lionakis
Jan 9, 2007·Experimental and Molecular Pathology·Akiko Ishida-OkawaraKazuo Suzuki
Aug 19, 2008·Mycoses·Cornelia SpethCornelia Lass-Flörl
Nov 20, 2008·Cellular Microbiology·Yanet ValdezB Brett Finlay
Apr 26, 2012·European Journal of Immunology·Shih-Chin ChengMihai G Netea
Feb 9, 2011·Molecular Microbiology·Christopher AskewMalcolm Whiteway
Feb 24, 2006·Atherosclerosis·Olga SteinYechezkiel Stein
Mar 19, 2015·Virulence·Seána DugganOliver Kurzai
Sep 22, 2015·Nature Reviews. Immunology·Mihai G NeteaFrank L van de Veerdonk
Dec 29, 2011·Molecular and Cellular Biochemistry·Hao Zheng, Yong-Sheng Yu
Nov 7, 2019·Journal of Immunology Research·Lorena BaviaLourdes Isaac
Jun 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irena RadovanovicPhilippe Gros
Oct 23, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David Torres-TiradoRafael Rubio
Apr 2, 2020·Frontiers in Cellular and Infection Microbiology·Dhirendra Kumar SinghAttila Gácser
Jul 3, 2021·International Journal of Molecular Sciences·Jonothan Rosario-ColonHong Xin

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