Dysregulated peripheral endocannabinoid system signaling is associated with cognitive deficits in first-episode psychosis

Journal of Psychiatric Research
Miquel BioqueFLAMM-PEPs Study - Centro de Investigación Biomédica en Red de Salud Mental

Abstract

Among etiological explanations for psychosis, several hypotheses involving alterations on the immune/inflammatory system have been proposed. The endocannabinoid system (ECS) is an endogenous neuroprotective, anti-inflammatory system that modulates cognitive processes. Its altered expression has been associated with psychotic disorders. 73 patients with a first episode of psychoses (FEP) and 67 healthy controls were recruited in 5 university centers in Spain. The protein expression of the main peripheral ECS components was determined in peripheral blood mononuclear cells. The cognition function was assessed following the MATRICS consensus. After controlling for potential confounding factors, working memory statistically correlated to the peripheral N-acyl phosphatidylethanolamine phospholipase expression (p = 0.039). The short-term verbal memory correlated to the Diacylglycerol lipase (p = 0.043) and the fatty acid amide hydrolase (p = 0.026) expression. Finally, attention measures correlated to the Monoacylglycerol lipase expression, by means of the CPT-II commissions (p = 0.036) and detectability (p = 0.026) scores. The ECS may regulate the activation of key mediators in immune and inflammatory responses that may be involved i...Continue Reading

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Citations

Jun 14, 2016·Revista de psiquiatrí́a y salud mental·Leticia Garcia-AlvarezJulio Bobes
Feb 26, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Teresa Sánchez-GutiérrezAna Calvo
May 13, 2020·Frontiers in Psychiatry·Francisco NavarreteJorge Manzanares
Mar 4, 2021·Reviews in the Neurosciences·Tomasz BielawskiDorota Frydecka
Jul 1, 2021·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Rodrigo FerretjansJoão V Salgado
Oct 31, 2021·The European Journal of Neuroscience·Helena P G JoaquimWagner F Gattaz

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