Abstract
Currently, the clinical dynamics of glucagon need to be revised based on previous data obtained from conventional glucagon radioimmunoassays. In the present study, we evaluated plasma glucagon levels in type 1 diabetes patients using a newly-developed sandwich enzyme-linked immunosorbent assay, and its association with clinical parameters and markers of diabetes complications were statistically assessed. The plasma glucagon level in 77 Japanese type 1 diabetes patients was 28.1 ± 17.7 pg/mL, and comparable with that reported previously for type 2 diabetes patients. However, the values were widely spread and did not correlate with plasma glucose values. Additionally, the average glucagon levels in patients in a hypoglycemic state (glucose level <80 mg/dL) did not increase (21.7 ± 12.2 pg/mL). The average glucagon level of patients experiencing hypoglycemia unawareness was significantly lower. Plasma glucagon levels evaluated using the new enzyme-linked immunosorbent assay were dysregulated in type 1 diabetes patients in respect to plasma glucose levels, suggesting dysregulation of secretion.
References
Oct 1, 1992·Diabetes Care·R KawamoriT Kamada
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira YamashinaYoshio Yamamoto
Apr 10, 2009·Cell Metabolism·Dan KawamoriRohit N Kulkarni
Mar 11, 2010·Advances in Experimental Medicine and Biology·Dan KawamoriRohit N Kulkarni
Aug 17, 2011·Diabetes, Obesity & Metabolism·D KawamoriR N Kulkarni
Dec 15, 2011·Endocrinology·Philip E Cryer
Jan 15, 2014·European Journal of Endocrinology·Monika J BakJens J Holst
Jun 4, 2014·Diabetologia·Nicolai J Wewer AlbrechtsenJens J Holst
Oct 27, 2014·Current Diabetes Reports·Asger LundTina Vilsbøll
Feb 2, 2016·Diabetes Research and Clinical Practice·Saeko OsawaIichiro Shimomura
Jun 23, 2016·Journal of Diabetes Investigation·Toshihiro MatsuoMitsuyoshi Namba
Oct 19, 2016·Biomarkers in Medicine·Nicolai J Wewer AlbrechtsenJens J Holst
Jan 22, 2017·Diabetes·Jens J HolstFilip K Knop
Apr 21, 2017·PloS One·Takashi KatsuraIichiro Shimomura
Aug 13, 2017·Analytical and Bioanalytical Chemistry·Atsushi MiyachiTadahiro Kitamura
Citations
Jun 16, 2018·Journal of Diabetes Investigation·Dan Kawamori
Aug 30, 2019·Journal of Diabetes Investigation·Dan KawamoriIichiro Shimomura
Apr 17, 2020·Journal of Diabetes Investigation·Dan Kawamori
May 30, 2019·Diabetology International·Misa KambaraTetsuya Babazono
Nov 2, 2020·Canadian Journal of Diabetes·Hidetaka Hamasaki, Shingo Morimitsu
Aug 28, 2021·Antioxidants·Yuqing TanWallace Yokoyama