Dysregulated TFR and TFH cells correlate with B-cell differentiation and antibody production in autoimmune hepatitis.

Journal of Cellular and Molecular Medicine
Ma LiangChen Jianping

Abstract

Follicular helper T (TFH) cell provides germinal centre (GC) B cell with critical signals for autoantibody production in the immunopathogenesis and progression of autoimmune hepatitis (AIH). However, the immunoregulatory functions of follicular regulatory T (TFR) cell in AIH are still unclear. The numbers of circulating TFR/TFH cells were measured in AIH patients. Moreover, we established experimental autoimmune hepatitis (EAH) model to examine the function of TFR cells on B-cell differentiation and autoantibody production in vivo and vitro. AIH patients had significantly increased numbers of TFH cells and decreased numbers of TFR cells as well as imbalanced TFR/TFH-type cytokines (IL-10, TGF-β1 and IL-21) compared with healthy controls (HCs). In addition, TFR cell numbers negatively correlated with TFH cell numbers. Also, serum hypergammaglobulinaemia (IgG and IgM) concentration negatively correlated the levels of serum IL-21, but positively correlated with the levels of serum IL-10 in AIH patients. Furthermore, in comparison with control group, significantly higher frequencies of spleen TFR cells but lower frequencies of spleen TFH cells were detected in the EAH group. Further analysis found that TFR cells simultaneously expr...Continue Reading

References

Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanessa L BryantStuart G Tangye
Jul 25, 2009·Science·Roza I NurievaChen Dong
Oct 12, 2010·Autoimmunity Reviews·Lea Campos OliveiraAnna Carla Goldberg
Feb 15, 2011·Annual Review of Immunology·Shane Crotty
Jul 26, 2011·Nature Medicine·Michelle A LintermanCarola G Vinuesa
Oct 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ivonne WollenbergLuis Graca
Jun 19, 2013·Lancet·Michael A HeneghanMaria Serena Longhi
Jul 6, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Liang MaYanfang Jiang
Mar 8, 2014·Immune Network·Hong-Jai ParkJe-Min Choi
May 9, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rodrigo LiberalMaria Serena Longhi
Jun 21, 2015·Trends in Immunology·Peter T Sage, Arlene H Sharpe
Jul 25, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaoming LiuYiwei Chu
Sep 16, 2015·The Journal of Experimental Medicine·Alison M PatersonArlene H Sharpe
Sep 25, 2017·Scandinavian Journal of Immunology·J ZhengL Cui

❮ Previous
Next ❯

Citations

Jan 2, 2021·Frontiers in Neurology·Ying WuOliver A Garden
Dec 15, 2020·Current Opinion in Gastroenterology·Anaïs CardonAmédée Renand
Dec 10, 2020·Journal of Immunology Research·Lin LiJiancheng Xu
Jul 11, 2020·Journal of Hepatology·Amédée RenandSophie Conchon
May 4, 2021·Inflammation and Regeneration·He HaoYoshiya Tanaka

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation
flow cytometry
ELISA
FCS
flow
FACS

Software Mentioned

SPSS

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.