Dysregulated Th1 and Th2 responses in food-allergic children--does elimination diet contribute to the dysregulation?

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Sara TomicićMalin Fagerås Böttcher

Abstract

Infants with eczema and sensitization to foods are recommended skin care and, if food allergy is proven, an elimination diet. Although most of these children tolerate foods before 3 yr of age, some children experience prolonged food allergy. To our knowledge, no prospective study has investigated the cytokine profile in food-sensitized eczematous children with prolonged food intolerance. The aim of the study was to prospectively investigate the development of cytokine production induced by food allergen in food-sensitized eczematous children who, at 4(1/2) yr of age, were allergic or tolerant to egg or milk. Twenty-one eczematous infants, [age 5 (3-10) months; median and range], sensitized to egg and/or milk were included, put on elimination diet and followed prospectively. At 4(1/2) yr of age, the children were defined as tolerant or allergic to egg and/or milk based on open or double-blind placebo-controlled food challenges. Peripheral blood mononuclear cells (PBMC) were isolated from the children on inclusion, after 6 wk of elimination diet, and at 3 and 4(1/2) yr of age. Ovalbumin, beta-lactoglobulin and tetanus toxoid-induced IL-4, -5, -10, -13 and IFN-gamma production from PBMC were analyzed with enzyme-linked immunosorbe...Continue Reading

References

Nov 1, 1985·The Journal of Pediatrics·H A Sampson, C C McCaskill
Nov 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·G HattevigB Björkstén
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology
Nov 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T NomaM Baba
May 7, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B HesselmarB Björkstén
Sep 1, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C MacaubasP G Holt
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·B Björkstén
Oct 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M C JenmalmB Salman
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Rogier P SchadeEls Van Hoffen
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Matthew S PerzanowskiBo Lundbäck
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kayhan T Nouri-AriaStephen R Durham
Jun 16, 2004·The Journal of Experimental Medicine·Malin R KarlssonPer Brandtzaeg
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Mübeccel AkdisCezmi A Akdis
Nov 22, 2005·Acta Paediatrica·Gunilla NorrmanKarin Fälth-magnusson
Jun 24, 2006·Allergy·B NiggemannK Beyer
Aug 30, 2006·Acta Paediatrica·Irene DevenneyKarin Fälth-Magnusson
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Ariana D BuchananA Wesley Burks
Aug 8, 2007·The Journal of Allergy and Clinical Immunology·Barbara BohleChristof Ebner
Dec 26, 2007·The Journal of Allergy and Clinical Immunology·Giorgio LongoAlessandro Ventura

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Citations

Dec 1, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Alexandra F Santos, Gideon Lack
Nov 7, 2014·Allergy, Asthma & Immunology Research·Wu HuiyanTao Ailin
Feb 9, 2017·International Immunology·Shota ToyoshimaRyo Abe

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