Abstract
Autoimmune disease (AID) patients always present with increased risk of psychiatric disorders, and thyroid function or thyroid hormone may play a critical role in the development of anxiety and depression. Thus, this study aimed to assess the free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroid-stimulating hormone (TSH) levels, and their correlations with anxiety/depression in patients with AID. Ninety-eight AID patients and 100 health controls (HCs) were recruited. Serum samples were obtained from all the participants to detect FT3, FT4, and TSH levels. Anxiety and depression were determined using the HADS assessment. HADS-Anxiety score, anxiety subject percentage, HADS-Depression score, and depression subject proportion were elevated in AID patients compared with HCs. FT3 and FT4 were downregulated while TSH was upregulated in AID patients compared with HCs. In AID patients, FT3 and FT4 negatively correlated with HADS-Anxiety score, and they were downregulated in patients with anxiety compared to patients without anxiety. Meanwhile, FT3 and FT4 were negatively associated while TSH level positively associated with HADS-Depression score. Besides, FT3 and FT4 reduced, but TSH level was of no difference in patients...Continue Reading
References
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jan 22, 2003·European Journal of Endocrinology·Anthony P Weetman
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Jul 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Patrick H DesseinAnne E Stanwix
Aug 20, 2004·BMC Psychiatry·Mauro Giovanni CartaStefano Mariotti
Jul 29, 2006·Irish Journal of Medical Science·Y ZyrianovaT G Dinan
Oct 10, 2006·Autoimmunity Reviews·Susan A GauthierHoward L Weiner
May 25, 2007·CNS Drugs·Isin Baral Kulaksizoglu
May 21, 2008·Lupus·B H Hahn, M McMahon
Aug 6, 2011·Nature Reviews. Immunology·Michael R Irwin, Steven W Cole
Mar 6, 2012·Autoimmunity Reviews·Scott M Hayter, Matthew C Cook
May 31, 2012·Endocrine·Donald S A McLeod, David S Cooper
Nov 12, 2013·General Hospital Psychiatry·Medine Giynas AyhanMehmet Sait Gonen
Mar 18, 2015·Social Psychiatry and Psychiatric Epidemiology·Till IttermannHans J Grabe
Jan 13, 2016·Iranian Red Crescent Medical Journal·Nakisa RasaeiMohammad Ali Nazarinia
Mar 19, 2016·Lupus·E A MacêdoL T L Costallat
Sep 11, 2016·Clinical Neurology and Neurosurgery·Mohammad Ali SahraianAbdorreza Naser Moghadasi
Dec 27, 2016·Journal of the Neurological Sciences·Rosa E BoeschotenBernard M J Uitdehaag
Jun 28, 2017·Psychoneuroendocrinology·Soledad Bárez-LópezAna Guadaño-Ferraz
Jul 18, 2017·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yu-Chuan LiuLin-Shien Fu
Apr 17, 2018·PloS One·Margarida Figueiredo-BragaBrian D Poole
May 23, 2018·Brain, Behavior, and Immunity·Yun-Hong CheonSang-Il Lee
Jul 12, 2018·Medicine·Margarida Figueiredo-BragaBrian D Poole
Sep 27, 2018·Current Rheumatology Reviews·Andrew KwanZahi Touma
Oct 31, 2018·Lupus·W LuoZ Yang
Jan 16, 2019·JAMA Network Open·Kristin WaldenlindJohan Askling
Apr 12, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xinyu HuangYonghong Xu
Jun 18, 2019·Best Practice & Research. Clinical Rheumatology·Hussein MahagnaHoward Amital
Jun 20, 2019·Digestive Diseases·Yu TangYan Zhang
Aug 14, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A BogdanV Bril
Dec 25, 2019·Neurosciences : the Official Journal of the Pan Arab Union of Neurological Sciences·Habib Erensoy