Dysregulation of Aldosterone Secretion in Mast Cell-Deficient Mice

Hypertension
Hadrien-Gaël BoyerEstelle Louiset

Abstract

Resident adrenal mast cells have been shown to activate aldosterone secretion in rat and man. Especially, mast cell proliferation has been observed in adrenal tissues from patients with aldosterone-producing adrenocortical adenoma. In the present study, we show that the activity of adrenal mast cells is stimulated by low-sodium diet and correlates with aldosterone synthesis in C57BL/6 and BALB/c mice. We have also investigated the regulation of aldosterone secretion in mast cell-deficient C57BL/6 KitW-sh/W-sh mice in comparison with wild-type C57BL/6 mice. KitW-sh/W-sh mice submitted to normal sodium diet had basal plasma aldosterone levels similar to those observed in wild-type animals. Conversely, low-sodium diet unexpectedly induced an exaggerated aldosterone response, which seemed to result from an increase in adrenal renin and angiotensin type 1 receptor expression. Severe hyperaldosteronism was associated with an increase in systolic blood pressure and marked hypokalemia, which favored polyuria. Adrenal renin and angiotensin type 1 receptor overexpression may represent a compensatory mechanism aimed at activating aldosterone production in the absence of mast cells. Finally, C57BL/6 KitW-sh/W-sh mice represent an unexpecte...Continue Reading

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Citations

Aug 22, 2020·American Journal of Hypertension·Nathanne S FerreiraErnesto L Schiffrin
Jul 4, 2021·Molecular and Cellular Endocrinology·Antoine-Guy LopezEstelle Louiset
Sep 28, 2021·The Journal of Clinical Endocrinology and Metabolism·Kelly De SousaMaria-Christina Zennaro

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