Dysregulation of amino acids and lipids metabolism in schizophrenia with violence

BMC Psychiatry
Xiacan ChenJunmei Hu

Abstract

Many studies have related biochemical characteristics to violence and have reported schizophrenia could elevated the risk of violent behaviour. However, the metabolic characteristics of schizophrenia patients with violence (V.SC) are unclear. To explore the metabolic characteristics of schizophrenia with violence and to identify potential biomarkers, untargeted metabolomics was performed by using gas chromatography time-of-flight mass spectrometry to analyse the plasma metabolites of fifty-three V.SC and twenty-four schizophrenia patients without violence (NV.SC). Multivariate and univariate analyses were performed to identify differential metabolites and biomarkers. Violence was assessed by the MacArthur Violence Assessment Study method. Psychiatric symptoms were assessed by the Positive and Negative Syndrome Scale. Multivariate analysis was unable to distinguish V.SC from NV.SC. Glycerolipid metabolism and phenylalanine, tyrosine and tryptophan biosynthesis were the differential metabolic pathways between V.SC and NV.SC. We confirmed ten metabolites and five metabolites as metabolic biomarkers of V.SC by random forest and support vector machine analysis, respectively. The biomarker panel, including the ratio of L-asparagine t...Continue Reading

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Citations

Mar 14, 2021·Scientific Reports·A M WhippJ Kaprio
Nov 2, 2021·Frontiers in Genetics·Vipul Vilas WaghSatyajeet P Khare

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Methods Mentioned

BETA
PCA

Software Mentioned

MPEA
Boruta
MPS2
R
OPLS
Xplore MET
DA
R package

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