Dysregulation of angiotensin II synthesis is associated with salt sensitivity in the spontaneous hypertensive rat

Acta Physiologica Scandinavica
G HodgeK A Duggan

Abstract

(1) Salt sensitive hypertension, which occurs as a result of treatment with nitric oxide synthase inhibitors, is associated with a loss of the usual down-regulatory effect of dietary sodium on angiotensin II (Ang II) synthesis. In the spontaneous hypertensive rat (SHR), which suffers a relative NO deficiency, the hypertension is in part salt sensitive. We sought to determine therefore whether the salt sensitive component to the hypertension was associated with a loss of the regulatory effect of dietary sodium on Ang II synthesis. (2) Male SHR were placed on low, intermediate or high salt diets for 4 weeks and their blood pressure recorded. After 4 weeks, blood was collected for determination of renin, angiotensinogen, Ang I, Ang II and aldosterone concentrations, as well as ACE activity. (3) The increase in systolic blood pressure in rats on the high salt diet was significantly greater than in those on the low (P < 0.005) and intermediate salt diets (P < 0.0005). Plasma renin and aldosterone concentrations and ACE activity decreased with increasing dietary sodium. However, the concentrations of Ang II and angiotensinogen both increased in the rats on the high salt diet (Ang II: P < 0.05; angiotensinogen: P < 0.05). (4) We concl...Continue Reading

References

Feb 1, 1987·Clinical Science·K A Duggan, G J Macdonald
Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·L K DahlK Thompson
Sep 1, 1996·Experimental Physiology·J Alaghband-ZadehJ F Laycock
Mar 4, 1999·The Korean Journal of Internal Medicine·S W KimY J Kang
Apr 2, 1999·Journal of Korean Medical Science·W Lee, Y Kwak
May 26, 1999·American Journal of Hypertension·C C Wu, M H Yen
Jun 16, 2001·American Journal of Physiology. Renal Physiology·Y QuirozB Rodríguez-Iturbe
Jun 16, 2001·American Journal of Physiology. Renal Physiology·D M Pollock, J S Pollock
Jul 4, 2001·Kidney & Blood Pressure Research·M R TrollietJ Loscalzo

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Citations

Feb 25, 2011·Journal of Hypertension·Dinko SusicL Gabriel Navar
Nov 3, 2010·American Journal of Nephrology·Jasmina VaragicCarlos M Ferrario
Dec 1, 2009·Therapeutic Advances in Cardiovascular Disease·Jasmina VaragicCarlos M Ferrario
Sep 22, 2009·European Journal of Pharmacology·Tatsuhiko MoriYasuo Matsumura
Jul 15, 2004·Seminars in Nephrology·Ming-Sheng ZhouLeopoldo Raij
Jun 30, 2005·The Veterinary Journal·A R Michell
Oct 2, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Bing S HuangFrans H H Leenen
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·Edward D Frohlich, Jasmina Varagic
Jul 11, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mark C ChappellBrian M Westwood
Feb 2, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dinko SusicEdward D Frohlich
May 8, 2019·Cell Biology International·Bruna F BrunPaula F Vassallo
Nov 20, 2018·Clinical and Experimental Hypertension : CHE·Jialiang WangChunyu Zeng

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