PMID: 11317070Apr 24, 2001Paper

Dysregulation of beta-chemokines in the lungs of HIV-1-infected patients

Journal of Acquired Immune Deficiency Syndromes : JAIDS
H AungZ Toossi

Abstract

The beta-chemokines, macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, monocyte chemotactic protein (MCP)-1 and regulated-on-activation normal T cell, expressed and secreted (RANTES) are not only chemotactic for mononuclear cells but may be important in suppression of HIV-1 replication through competitive binding to the chemokine receptor, CCR5, which is critical to viral entry. In this study, bronchoalveolar cells (BACs) and autologous peripheral blood mononuclear cells (PBMCs) were obtained from HIV-1-infected participants who did not manifest clinical signs of lung disease with peripheral CD4 T-cell count >200/mm(3) (n = 7, group with high CD4 count), or CD4 T-cell count <200/mm(3) (n = 12, group with low CD4 count), and from healthy study subjects (n = 5). The capacity to express beta-chemokines and CCR5 was assessed. Induction of MIP-1 alpha by lipopolysaccharide (LPS) in BAC of HIV-1-infected study subjects from the low CD4 group was less than BAC from healthy study subjects (p <.001), and also was less than in BACs from the group with a high CD4 group (p <.001). Moreover, the intracellular expression of MIP-1 alpha in LPS-induced monocytes of HIV-1-infected patients was significantly less than that from healthy ...Continue Reading

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Citations

May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satish L DeshmaneBassel E Sawaya
Dec 15, 2015·Pathogens and Disease·Gregory H TaylorAlfredo Garzino-Demo
Mar 30, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vernon C Maino, Holden T Maecker
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiko HoshinoMichael Weiden

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