Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy.

Anesthesia and Analgesia
Chiang Siau, Gary J Bennett

Abstract

Paclitaxel and vincristine are chemotherapeutic drugs that often evoke a long-lasting painful peripheral neuropathy. Using drugs that reduce intracellular or extracellular calcium ions (Ca2+), we investigated the hypothesis that impaired Ca2+ regulation contributes to the chemotherapy-evoked neuropathic pain syndrome. For comparison, we also tested rats with painful peripheral neuropathy caused by nerve trauma and to the anti-human immunodeficiency virus nucleoside analog 2',3'-dideoxycytidine (ddC). Normal naïve (without neuropathy), paclitaxel-treated, and vincristine-treated rats received the following intrathecal injections: TMB-8 (46 nmol), Quin-2 (1.8 nmol), EGTA (0.1 micromol), EGTA-am (0.1 micromol), and their vehicle controls. Chronic constriction injury (CCI) rats were examined after TMB-8 and Quin-2 injections, and ddC-treated rats were examined after receiving TMB-8. Mechano-allodynia and mechano-hyperalgesia were evaluated after each injection. Drug effects on heat hyperalgesia were also tested in CCI rats. All four Ca2+-reducing drugs significantly inhibited mechano-allodynia and mechano-hyperalgesia in the rats treated with paclitaxel, vincristine, or ddC, but no effects were seen in the CCI or naïve rats. We con...Continue Reading

References

Jun 1, 1986·Pharmacological Research Communications·C TariA Crevat
Jun 17, 1983·European Journal of Pharmacology·M M Ben-SretiR D Sewell
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Nov 29, 2001·The Journal of Biological Chemistry·Jackie F KiddPeter Thorn
Apr 17, 2002·Journal of Neurology·Stefan Quasthoff, Hans Peter Hartung
Apr 2, 2004·Nature Reviews. Cancer·Mary Ann Jordan, Leslie Wilson

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Citations

Mar 3, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Amteshwar Singh Jaggi, Nirmal Singh
Nov 23, 2011·International Journal of Clinical Oncology·Yuko TanabeYasuhiro Fujiwara
Dec 15, 2010·Journal of Natural Medicines·Arunachalam MuthuramanAmteshwar S Jaggi
Mar 16, 2011·Journal of Natural Medicines·Arunachalam Muthuraman, Nirmal Singh
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thierry Bordet, Rebecca M Pruss
Aug 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michelle MoBarbara E Ehrlich
Jul 31, 2008·The Journal of Pharmacology and Experimental Therapeutics·Elizabeth J RahnAndrea G Hohmann
Aug 6, 2010·Biological & Pharmaceutical Bulletin·Gurpreet KaurNirmal Singh
Nov 17, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Nobuaki EgashiraRyozo Oishi
Jun 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang BoehmerleBarbara E Ehrlich
Dec 18, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dun LingluYu Jianqiang
May 9, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robert L MasseySalahadin Abdi
Jul 30, 2014·Archives of Toxicology·Andreas A ArgyriouHaralabos P Kalofonos
Sep 9, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Wenhua XiaoGary J Bennett
Jun 12, 2012·Clinical Colorectal Cancer·Augusta N UwahWilliam Tester
Nov 26, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Takehiro KawashiriRyozo Oishi
Dec 20, 2007·The Journal of Pain : Official Journal of the American Pain Society·C Richard ChapmanChan Woo Song
Nov 13, 2007·British Journal of Pharmacology·J Guindon, A G Hohmann
Dec 3, 2014·Neuroscience Letters·V A CarozziA Chiorazzi
Mar 3, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shrutya BhallaAmteshwar Singh Jaggi
Feb 14, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amteshwar Singh Jaggi, Nirmal Singh
Jan 31, 2012·Toxicology and Industrial Health·Venkata Rathina Kumar ThiagarajanNirmal Singh

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