Dysregulation of developmental pathways in bone metastasis

Bone
Nilay Sethi, Yibin Kang

Abstract

It is well-known that pathways normally functioning during embryonic development are dysregulated in cancer. Experimental and clinical studies have established strong connections between aberrant developmental pathways and transformation, as well as other early stage events of cancer progression. There is now emerging evidence that also indicates the contribution of developmental pathways to the pathogenesis of distant metastasis, including bone metastasis. In particular, the Wnt, BMP, and Hedgehog signaling pathways have all been implicated in the development of bone metastasis. These developmental pathways participate in the regulation of cell-autonomous functions in tumor cells as well as tumor-stromal interactions in the bone microenvironment, eventually promoting the formation of osteolytic or osteoblastic bone metastasis.

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Citations

Jul 17, 2012·Wiener medizinische Wochenschrift·Reinhard Gruber
Sep 24, 2011·Nature Reviews. Cancer·Nilay Sethi, Yibin Kang
Aug 15, 2014·BoneKEy Reports·Brian Ell, Yibin Kang
Jun 19, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Shawn A McClureRobert A Ord
Oct 27, 2011·BMB Reports·Meejung Kim, Senyon Choe
Aug 26, 2014·Bone Marrow Research·Fakher RahimNajmaldin Saki
Jun 13, 2015·Journal of Immunology Research·Lucia D'Amico, Ilaria Roato
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Jun 1, 2013·International Journal of Molecular Sciences·Chia-Hsien LeeHsueh-Fen Juan
Nov 15, 2011·British Journal of Cancer·N Sethi, Y Kang
May 18, 2016·Endocrinology and Metabolism·Yibin Kang
May 22, 2018·Frontiers in Endocrinology·Marie-Therese Haider, Hanna Taipaleenmäki
Jul 6, 2019·Frontiers in Pharmacology·Julien VollairePascale A Cohen

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