Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice

Development
Henry MokArmin Schumacher

Abstract

Regulatory interferences at the iron transporter ferroportin 1 (Fpn1) cause transient defects in iron homeostasis and erythropoiesis in polycythaemia (Pcm) mutant mice. The present study identified decreased Fpn1 expression in placental syncytiotrophoblast cells at late gestation as the mechanism of neonatal iron deficiency in Pcm mutants. Tissue specificity of embryonic Fpn1 dysregulation was evident from concomitant decreases in Fpn1 mRNA and protein expression in placenta and liver, as opposed to upregulation of Fpn1 protein despite decreased transcript levels in spleen, implicating post-transcriptional regulation of Fpn1. Dysregulation of Fpn1 and decreased iron levels in Pcm mutant spleens correlated with apoptotic cell death in the stroma, resulting in a semidominant spleen regression. At 7 weeks of age, a transient increase in spleen size in Pcm heterozygotes reflected a transient erythropoietin-mediated polycythemia. Structurally, Pcm mutant spleens displayed a severe defect in red pulp formation, including disruption of the sinusoidal endothelium, as well as discrete defects in white pulp organization during postnatal development. Reduced functional competence of the Pcm mutant spleen was manifested by an impaired resp...Continue Reading

References

Feb 1, 1972·The American Journal of Physiology·B B Lozzio
Sep 1, 1970·The American Journal of Physiology·C E BozziniC E Epper
Apr 21, 1994·Nature·C W RobertsS J Korsmeyer
Aug 15, 1994·FEBS Letters·K FukuchiK Gomi
Aug 27, 1993·Cell·J A KreidbergR Jaenisch
Jun 8, 1999·Annual Review of Immunology·Y X Fu, D D Chaplin
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·L A LetticeR E Hill
Sep 2, 1999·Current Biology : CB·U HerzerC Englert
Nov 11, 1999·European Journal of Immunology·C García De VinuesaI C MacLennan
Apr 5, 2000·The Journal of Biological Chemistry·S Abboud, D J Haile
May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K KoehlerT N Dear
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·R K Bruick
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·J LuE N Olson
Dec 13, 2000·The Journal of Biological Chemistry·C H ParkT Ganz
Jul 27, 2001·The International Journal of Biochemistry & Cell Biology·P AisenM Wessling-Resnick
Nov 10, 2001·Annual Review of Genomics and Human Genetics·N C Andrews
Feb 8, 2002·The Journal of Biological Chemistry·Atsushi MizutaniShigeru Taketani
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gaël NicolasSophie Vaulont
Sep 21, 2002·Biochimica Et Biophysica Acta·Nghia T V Le, Des R Richardson
Oct 9, 2002·Apoptosis : an International Journal on Programmed Cell Death·J K Brunelle, N S Chandel
Jan 28, 2003·Blood Cells, Molecules & Diseases·Xiao-bing LiuDavid J Haile
Feb 8, 2003·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·H J McArdleL Gambling
Jul 2, 2003·Pflügers Archiv : European journal of physiology·Andrew T McKie, David J Barlow
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Oct 31, 1959·Nature·A G SEARLE
Apr 28, 2004·Cell·Matthias W HentzeNancy C Andrews

❮ Previous
Next ❯

Citations

Sep 29, 2011·Biological Trace Element Research·Yan-Qin LiGui-Hua Zhuang
Sep 9, 2011·Seminars in Liver Disease·Ivana De DomenicoJerry Kaplan
Apr 1, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hanaâ BerradiIsabelle Dublineau
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Phillip S Oates, Umbreen Ahmed
Apr 30, 2009·Annual Review of Pathology·Pauline L Lee, Ernest Beutler
Mar 29, 2008·Blood·Prasad N ParadkarDiane McVey Ward
Sep 15, 2005·Genetics·Rodrigo Fernández-ValdiviaArmin Schumacher
Sep 10, 2010·Advances in Hematology·Luciano CianettiNadia Maria Sposi
Apr 26, 2006·European Journal of Clinical Investigation·R Deicher, W H Hörl
Dec 16, 2011·Cell Biochemistry and Function·Yan-Qin LiGui-Hua Zhuang
Jul 15, 2009·Brain Research·Jared IacovelliArmin Schumacher
Mar 24, 2012·Biochimica Et Biophysica Acta·Diane M Ward, Jerry Kaplan
Jul 2, 2014·Frontiers in Pharmacology·De-Liang ZhangTracey A Rouault
Jun 5, 2016·Nutrition Reviews·Chang Cao, Mark D Fleming
Jan 19, 2006·The Journal of Biological Chemistry·Henry MokArmin Schumacher
Jan 30, 2007·The Journal of Biological Chemistry·Se Young KimArmin Schumacher
May 26, 2020·Reproduction in Domestic Animals = Zuchthygiene·Kandasamy RajamanickamAngappan Mangala Gowri
Oct 18, 2020·Pediatric Research·E A McDonaldJ F Friedman
Aug 15, 2021·Seminars in Hematology·Samira Lakhal-Littleton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis