Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility

Molecular and Cellular Endocrinology
Sheena L P ReganGhanim Almahbobi

Abstract

Reproductive ageing is linked to the depletion of ovarian primordial follicles, which causes an irreversible change to ovarian cellular function and the capacity to reproduce. The current study aimed to profile the expression of bone morphogenetic protein receptor, (BMPR1B) in 53 IVF patients exhibiting different degrees of primordial follicle depletion. The granulosa cell receptor density was measured in 403 follicles via flow cytometry. A decline in BMPR1B density occurred at the time of dominant follicle selection and during the terminal stage of folliculogenesis in the 23-30 y good ovarian reserve patients. The 40+ y poor ovarian reserve patients experienced a reversal of this pattern. The results demonstrate an association between age-induced depletion of the ovarian reserve and BMPR1B receptor density at the two critical time points of dominant follicle selection and pre-ovulatory follicle maturation. Dysregulation of BMP receptor signalling may inhibit the normal steroidogenic differentiation required for maturation in older patients.

References

Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·S ShimasakiG F Erickson
Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·P MulsantJ M Elsen
Dec 12, 2001·Biochemical and Biophysical Research Communications·R K MooreS Shimasaki
Apr 12, 2002·Endocrine Reviews·Mario AscoliDeborah L Segaloff
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Nanette SantoroDavid Barad
May 24, 2007·Molecular Human Reproduction·Shuping GaoHong Zhang
Jul 11, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Chantelle RuossGhanim Almahbobi
Oct 31, 2009·Endocrine Journal·Fumio Otsuka
Jun 5, 2010·Fertility and Sterility·Karl R HansenLaTasha B Craig
Aug 19, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Andrew N Shelling
Sep 28, 2010·Fertility and Sterility·Benny AlmogTogas Tulandi
Jul 22, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Jennifer L JuengelKenneth P McNatty
Feb 3, 2012·Reproductive Biomedicine Online·John YovichPeter Hinchliffe
Feb 10, 2012·European Journal of Human Genetics : EJHG·Alan H HandysideJoep Geraedts
Mar 28, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·J M YoungA S McNeilly
Jun 12, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sayaka Ogura-NoseYuji Taketani
Sep 10, 2013·Human Reproduction·R Anand-IvellR Ivell

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Citations

Mar 20, 2018·Frontiers in Endocrinology·Sheena L P ReganArun Dharmarajan
Nov 27, 2019·The Journal of Clinical Endocrinology and Metabolism·Lucie RenaultIsabelle Beau
Apr 18, 2020·Journal of Animal Science·Xiaoyan ZhangDavid P Casper
Jul 25, 2018·Journal of Assisted Reproduction and Genetics·Alexandra SanfinsDavid F Albertini
Oct 23, 2019·Frontiers in Endocrinology·John L YovichKevin N Keane

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