Dysregulation of markers of oxidative stress and DNA damage among nail technicians despite low exposure to volatile organic compounds

Scandinavian Journal of Work, Environment & Health
Peter GresnerWojciech Wasowicz

Abstract

The study aimed to compare levels of selected biomarkers of oxidative stress and DNA damage and their correlation with occupational exposure to volatile organic compounds (VOC) among female nail technicians and a group of unexposed volunteers. A panel of biomarkers of oxidative stress and DNA damage was assayed among 145 female nail technicians and 152 healthy female volunteers. Occupational exposure of nail technicians to VOC was assessed analyzing the VOC content in nail salon air samples. The level of occupational exposure of nail technicians to VOC was below the respective threshold limit values with combined airborne exposure to a mixture of VOC, reaching only 3.3% (range 0.2-33.3%) of the threshold limit. Despite that, nail technicians presented increased activity of glutathione peroxidase 1 (GPx1), plasma ceruloplasmin, and the GPx1/superoxide dismutase 1 ratio (P<0.0001). The levels of plasma thiobarbituric acid-reactive species and DNA strand breakage in blood leukocytes were not significantly different. In contrast, total and oxidatively-generated DNA damage were significantly decreased among nail technicians compared to controls (P<0.0001). The individual's current tobacco smoking and alcohol consumption status did n...Continue Reading

Citations

Mar 16, 2019·Annals of Global Health·Regina Montero-MontoyaOmar Arellano-Aguilar
Apr 19, 2019·Environmental Monitoring and Assessment·Mahbobeh MoradiAbbas Shahsavani
Nov 7, 2020·International Archives of Occupational and Environmental Health·Peter GrešnerJolanta Gromadzińska

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