Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor

Scientific Reports
K N FontesT M Ortiga-Carvalho

Abstract

Malaria in Pregnancy (MiP) is characterized by placental accumulation of Plasmodium-infected erythrocytes, intrauterine growth restriction (IUGR) and preterm delivery (PTD). Placental ATP-binding cassette (ABC) transporters mediate the efflux of nutrients, cytokines and xenobiotics. The expression and activity of these transporters are highly responsive to infection. We hypothesized that MiP would perturb the expression of placental ABC transporters, promoting PTD. Peripheral blood, spleens, livers and placentas of pregnant mice, infected with Plasmodium berghei ANKA on gestational day (GD) 13.5, were collected and analyzed on GD18.5. The primary consequences of human MiP, including IUGR, PTD (20%) and placental inflammation, were recapitulated in our mouse model. Electron microscopy revealed attenuated presence of labyrinthine microvilli and dilated spongiotrophoblasts -granular endoplasmic reticulum cisternae. Additionally, a decrease in placental Abca1 (ABCA1), Abcb1b (P-glycoprotein), Abcb9 and Abcg2 (BCRP) expression was observed in MiP mice. In conclusion, MiP associated with PTD impairs placental ABC transporters' expression, potentially modulating placental nutrient, environmental toxin and xenobiotic biodistribution wi...Continue Reading

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Citations

Aug 12, 2020·Journal of Cellular and Molecular Medicine·Lilian M MartinelliEnrrico Bloise
Oct 2, 2020·BMC Genomics·J L BrittS K Duckett
Nov 14, 2019·Nutrients·Valentine Suzanne Moullé, Patricia Parnet
May 16, 2021·American Journal of Reproductive Immunology : AJRI·Gerard AgbayaniLakshmi Krishnan
Jun 8, 2021·Frontiers in Immunology·Cherley Borba Vieira AndradeTania Maria Ortiga-Carvalho
Aug 17, 2021·Frontiers in Microbiology·Mila W ReginattoTania M Ortiga-Carvalho

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Methods Mentioned

BETA
light microscopy
electrophoresis

Software Mentioned

Graphpad prism
Image Pro Plus
Image J
STEPanizer

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