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Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis

Neurobiology of Disease

Jan 14, 2020

Trisha R StankiewiczDaniel A Linseman

Abstract

Rho GTPases play a central role in neuronal survival; however, the antagonistic relationship between Rac and Rho in the regulation of motor neuron survival remains poorly defined. In the current study, we demonstrate that treatment with NSC23766, a selective inhibitor of the Rac-specifi...read more

Mentioned in this Paper

Inhibitors
Copper
Mutant
Rho Factor
Cessation of Life
RAC1 wt Allele
Mice, Transgenic
Apoptosis
Mus
Terminal Illness
Paper Details
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Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis

Neurobiology of Disease

Jan 14, 2020

Trisha R StankiewiczDaniel A Linseman

PMID: 31931138

DOI: 10.1016/j.nbd.2020.104743

Abstract

Rho GTPases play a central role in neuronal survival; however, the antagonistic relationship between Rac and Rho in the regulation of motor neuron survival remains poorly defined. In the current study, we demonstrate that treatment with NSC23766, a selective inhibitor of the Rac-specifi...read more

Mentioned in this Paper

Inhibitors
Copper
Mutant
Rho Factor
Cessation of Life
RAC1 wt Allele
Mice, Transgenic
Apoptosis
Mus
Terminal Illness

Similar Papers Found In These Feeds

Parkinson's Disease: Animal Models

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on animal models used for Parkinson's disease research.

Focal Adhesions: Structure and Dynamics

Focal Adhesions are structures composed of integrins and other scaffolding proteins that link the extracellular matrix to the actin cytoskeleton. Discover the latest research on Focal Adhesions: Structure and Dynamics here.

Related Papers

Current Biology : CB

Rac and Rho

Current Biology : CBMarch 13, 1999
A Ridley
Current Biology : CB

Rac and Rho in control

Current Biology : CBDecember 1, 1992
P J Goldschmidt-ClermontJ B Gibbs
Paper Details
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  • Citations
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    References currently unavailable

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