Dysregulation of RNF213 promotes cerebral hypoperfusion

Scientific Reports
Takaaki MorimotoAkio Koizumi

Abstract

RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid artery stenosis surgery using external microcoils on Rnf213 knockout (KO) and vascular endothelial cell-specific Rnf213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice. Temporal CBF changes were measured by arterial spin-labelling magnetic resonance imaging. In the cortical area, no significant difference in CBF was found before surgery between the genotypes. Three of eight (37.5%) KO mice died after surgery but all wild-type and EC-Tg mice survived hypoperfusion. KO mice had a significantly more severe reduction in CBF on day 7 than wild-type mice (KO, 29.7% of baseline level; wild-type, 49.3%; p = 0.038), while CBF restoration on day 28 was significantly impaired in both KO (50.0%) and EC-Tg (56.1%) mice compared with wild-type mice (69.5%; p = 0.031 and 0.037, respectively). Changes in the subcortical area also showed the same tendency as the cortical area. Additionally, histological analysis demonstrated that angiogenesis was impaired in both EC-Tg and KO mice. These results are in...Continue Reading

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Citations

Nov 11, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shi-Jun LiLi-Qun Liu
Mar 19, 2020·International Journal of Molecular Sciences·Jinkwon KimNam Keun Kim
Jun 30, 2019·Alzheimer's Research & Therapy·Cristina M Pedrero-PrietoJuan R Peinado
Jan 19, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X WangX Zhu
Jan 24, 2021·BMC Neurology·Satoshi HosokiMasafumi Ihara
Mar 12, 2021·Clinical Neurology and Neurosurgery·Junyu LiuJunxia Yan
Sep 17, 2021·Translational Stroke Research·R MertensP Vajkoczy

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Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

ParaVison
LINUX
Image J
Osirix
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JMP

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