Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability

Journal of Neurochemistry
Kazuo KunisawaKazuhiro Ikenaka

Abstract

Myelinated axons segregate the axonal membrane into four defined regions: the node of Ranvier, paranode, juxtaparanode, and internode. The paranodal junction consists of specific component proteins, such as neurofascin155 (NF155) on the glial side, and Caspr and Contactin on the axonal side. Although paranodal junctions are thought to play crucial roles in rapid saltatory conduction and nodal assembly, the role of their interaction with neurons is not fully understood. In a previous study, conditional NF155 knockout in oligodendrocytes led to disorganization of the paranodal junctions. To examine if disruption of paranodal junctions affects neuronal gene expression, we prepared total RNA from the retina of NF155 conditional knockout, and performed expression analysis. We found that the expression level of 433 genes changed in response to paranodal junction ablation. Interestingly, expression of aquaporin 3 (AQP3) was significantly reduced in NF155 conditional knockout mice, but not in cerebroside sulfotransferase knockout (CST-KO) mice, whose paranodes are not originally formed during development. Copy number variations have an important role in the etiology of schizophrenia (SCZ). We observed rare duplications of AQP3 in SCZ p...Continue Reading

References

Jun 12, 1999·Biochemistry and Molecular Biology International·I A LeeI S Choe
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Koichi HonkeNaoyuki Taniguchi
Oct 9, 2002·Current Opinion in Neurobiology·Jean-Antoine Girault, Elior Peles
Dec 14, 2002·Genesis : the Journal of Genetics and Development·Nathalie H DoerflingerBrian Popko
Aug 5, 2003·Journal of Neuroscience Research·Matthew N RasbandJames S Trimmer
Mar 27, 2004·Science·Galin V MichailovKlaus-Armin Nave
Aug 5, 2005·Journal of Cell Science·A S Verkman
Mar 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·German P Garcia-FrescoManzoor A Bhat
Aug 19, 2007·Brain : a Journal of Neurology·Gwenaëlle DouaudAnthony James
Aug 24, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthias EckhardtVolkmar Gieselmann
Sep 21, 2007·Multiple Sclerosis : Clinical and Laboratory Research·R E Gonsette
May 12, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yoshihiko YamazakiHiroshi Kato
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hisataka TanakaKazuhiro Ikenaka
Sep 2, 2009·PloS One·Xiangning ChenKenneth S Kendler
Nov 12, 2010·Nature·Klaus-Armin Nave
Sep 7, 2011·Archives of General Psychiatry·Panos RoussosVahram Haroutunian
Jul 18, 2012·Nature·Youngjin LeeJeffrey D Rothstein
Sep 11, 2012·Journal of Neurodevelopmental Disorders·Bernard J Crespi, Helen J Crofts
Oct 30, 2012·International Journal of Cardiology·Marjolijn RenardJulie De Backer
Nov 13, 2012·Nature Neuroscience·Jia LiuPatrizia Casaccia
Oct 15, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jack RosenbluthSeema Shroff
Jan 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gülsen ÇolakoğluBarbara Ranscht
Sep 1, 2015·Psychiatry Research·Sebastian Walther
Jan 23, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jia LiuPatrizia Casaccia

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Citations

Oct 28, 2019·Mini Reviews in Medicinal Chemistry·Dervis DasdelenAbdülkerim Kasim Baltaci

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