Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis

The Journal of Clinical Investigation
T Wyss-CorayL Mucke

Abstract

HIV-1 associated central nervous system (CNS) disease involves neuronal damage and prominent reactive astrocytosis, the latter characterized by strong upregulation of the glial fibrillary acidic protein (GFAP) in astrocytes. Similar alterations are found in transgenic mice expressing the HIV-1 envelope protein gp120 in the CNS. Because alterations of astrocyte functions could contribute to neuronal impairment, we compared brains of gp120 transgenic mice and gp120-transfected C6 astrocytoma cells with controls and found that gp120 induced a prominent elevation of steady state GFAP mRNA levels, primarily due to transcript stabilization. Increased levels of GFAP mRNA were also found in nontransfected C6 cells exposed to recombinant gp120. Exposure of C6 cells or primary mouse astrocytes to soluble gp120 led to activation of PKC as indicated by redistribution and increase in PKC immunoreactivity at the single cell level. gp120 effects were diminished by inhibitors of protein kinase C (PKC) but not inhibitors of protein kinase A. PKC activity was upmodulated in gp120-transfected C6 cells and in the CNS of gp120 transgenic mice. Further, brain tissue from patients with HIV-1 encephalitis and from gp120 transgenic mice showed increase...Continue Reading

References

Dec 31, 1992·Annals of the New York Academy of Sciences·C R AbrahamL Mucke
Dec 1, 1992·Virology·J Schneider-SchauliesV Ter Meulen
Sep 1, 1992·Annals of Neurology·E MasliahC A Wiley
Jan 1, 1992·Cell Motility and the Cytoskeleton·A SpudichL Stryer
Feb 14, 1990·Biochemical and Biophysical Research Communications·I YasudaY Nishizuka
Apr 15, 1991·Biochemical and Biophysical Research Communications·R F BrunsH Nakano
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S BhatD H Silberberg
Jan 1, 1990·Annual Review of Genetics·J A AtwaterI M Verma
May 1, 1990·Immunology Today·Z F Rosenberg, A S Fauci
Feb 14, 1990·Biochemical and Biophysical Research Communications·N E ZornD H Russell
Nov 1, 1989·Annals of Neurology·J C McArthurD Price
Oct 4, 1988·Biochemistry·M D Bazzi, G L Nelsestuen
Feb 1, 1988·Annals of Neurology·T M LenhardtC A Wiley
Apr 1, 1987·Neurology·S M de la MonteE P Richardson
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B HofmannJ L Fahey
Aug 13, 1993·Cell·A B Sachs
Jul 1, 1994·Immunology Today·D Mosier, H Sieburg
Aug 1, 1994·Current Opinion in Immunology·T H Finkel, N K Banda
May 1, 1994·Journal of Neuropathology and Experimental Neurology·M D Norenberg
May 1, 1994·Journal of Neuropathology and Experimental Neurology·L C StanleyW S Griffin
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·D J BenosE N Benveniste
May 1, 1993·Neurochemistry International·K P Huang, F L Huang

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Citations

Nov 30, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ricky MaungMarcus Kaul
Nov 14, 2000·Biological Psychiatry·S M Brooke, R M Sapolsky
Jan 26, 1999·Cytokine & Growth Factor Reviews·E N Benveniste
May 15, 2004·DNA and Cell Biology·Roger J Pomerantz
May 21, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·N AvgeropoulosW R Tyor
Jan 5, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M B Huang, V C Bond
Aug 26, 2014·Cell and Tissue Research·Joon W ShimJoseph R Madsen
Jan 24, 2014·Japanese Journal of Infectious Diseases·Masatoshi KakizakiRihito Watanabe
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·X XuL Mucke
May 29, 2014·Journal of Neurovirology·Fabián J Vázquez-SantiagoVanessa Rivera-Amill
Jul 22, 1998·Journal of Neuroimmunology·B E SawayaS Amini
Jun 28, 2003·Neurotoxicity Research·Wojciech Danysz, Chris G Parsons
Jul 30, 2005·Journal of Biosciences·Hakan Ozdener
Mar 24, 2006·The European Journal of Neuroscience·Alexander KasyanovHuangui Xiong
Jan 3, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Uwe UeberhamThomas Arendt
Jun 27, 2019·Journal of Molecular Neuroscience : MN·Hriday Shanker Pandey, Pankaj Seth
Oct 9, 1999·Journal of Virology·R FriggA Aguzzi

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