Dysregulation of Stemness Pathways in HPV Mediated Cervical Malignant Transformation Identifies Potential Oncotherapy Targets.

Frontiers in Cellular and Infection Microbiology
Megha BudhwaniJanin Chandra

Abstract

Human papillomavirus (HPV) infection is associated with a range of malignancies that affect anogenital and oropharyngeal sites. α-HPVs dominantly infect basal epithelial cells of mucosal tissues, where they dysregulate cell division and local immunity. The cervix is one of the mucosal sites most susceptible to HPV infections. It consists of anatomically diverse regions, and the majority of cervical intraepithelial neoplasia and cancers arise within the cervical squamo-columnar junction where undifferentiated basal progenitor cells with stem cell properties are found. The cancer stem cell theory particularly associates tumorigenesis, invasion, dissemination, and metastasis with cancer cells exhibiting stem cell properties. In this perspective, we discuss evidence of a cervical cancer stem cell niche and explore the association of stemness related genes with 5-year survival using a publicly available transcriptomic dataset of a cervical cancer cohort. We report that poor prognosis in this cohort correlates with overexpression of a subset of stemness pathway genes, a majority of which regulate the central Focal Adhesion pathway, and are also found to be enriched in the HPV infection pathway. These observations support therapeutic ...Continue Reading

References

Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Gianfranco FaviaRosario Serpico
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher B BuckJohn T Schiller
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H Y WangS Q Fu
Dec 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Eun-Kyoung Yim, Jong-Sup Park
Jul 2, 2010·Nature Reviews. Cancer·Cary A Moody, Laimonis A Laimins
Jan 11, 2011·Trends in Microbiology·Michael HerfsPhilippe Delvenne
May 10, 2011·The American Journal of Pathology·Valentina VairaSilvano Bosari
May 15, 2012·International Journal of Oncology·Atsuki SatoZenya Naito
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael HerfsChristopher P Crum
Jan 24, 2013·The Open Virology Journal·Mandy Muller, Caroline Demeret
Dec 10, 2013·Seminars in Cancer Biology·Massimo Tommasino
Dec 11, 2014·International Journal of Cancer. Journal International Du Cancer·Stéphanie DemoulinPascale Hubert
May 16, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eric J YangMichael Herfs
Nov 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shanshan YangMin Xiao
Jun 28, 2016·Oncotarget·Ruixia Huang, Einar K Rofstad
Oct 25, 2016·Gynecologic Oncology·Alma Delia Campos-ParraCarlos Pérez-Plasencia
Dec 3, 2016·Nature Reviews. Disease Primers·Mark SchiffmanSilvia Franceschi
Jan 24, 2017·Nature·UNKNOWN Cancer Genome Atlas Research NetworkUNKNOWN Washington University in St Louis

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
biopsies

Software Mentioned

db
Xenabrowser
STRING
Enrichr

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JPMA. the Journal of the Pakistan Medical Association
Faisal Azam, Mohammad Shams-ul-Islam
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Soung Min Kim
© 2021 Meta ULC. All rights reserved