Dysregulation of striatal dopamine release in a mouse model of dystonia.

Journal of Neurochemistry
Li BaoMargaret E Rice

Abstract

Dystonia is a neurological disorder characterized by involuntary movements. We examined striatal dopamine (DA) function in hyperactive transgenic (Tg) mice generated as a model of dystonia. Evoked extracellular DA concentration was monitored with carbon-fiber microelectrodes and fast-scan cyclic voltammetry in striatal slices from non-Tg mice, Tg mice with a positive motor phenotype, and phenotype-negative Tg littermates. Peak single-pulse evoked extracellular DA concentration was significantly lower in phenotype-positive mice than in non-Tg or phenotype-negative mice, but indistinguishable between non-Tg and phenotype-negative mice. Phenotype-positive mice also had higher functional D2 DA autoreceptor sensitivity than non-Tg mice, which would be consistent with lower extracellular DA concentration in vivo. Multiple-pulse (phasic) stimulation (five pulses, 10-100 Hz) revealed an enhanced frequency dependence of evoked DA release in phenotype-positive versus non-Tg or phenotype-negative mice, which was exacerbated when extracellular Ca(2+) concentration was lowered. Enhanced sensitivity to phasic stimulation in phenotype-positive mice was reminiscent of the pattern seen with antagonism of nicotinic acetylcholine receptors. Consi...Continue Reading

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Citations

Aug 11, 2012·PloS One·Nicole BodePedro Gonzalez-Alegre
Jan 22, 2013·Bioanalysis·Michael A Johnson
Sep 24, 2011·Neuroscience·M E RiceS J Cragg
Dec 8, 2010·Neurobiology of Disease·D Cristopher BraggNutan Sharma
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Apr 13, 2021·Analytical and Bioanalytical Chemistry·Andrea Jaquins-GerstlAdrian C Michael
Jul 31, 2021·Frontiers in Aging Neuroscience·Anna GasiorowskaGrazyna Niewiadomska

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