Dysregulation of subcutaneous adipose tissue blood flow in overweight postmenopausal women

Menopause : the Journal of the North American Menopause Society
J AnderssonT Olsson

Abstract

A putative link between abdominal obesity and metabolic-vascular complications after menopause may be due to a decreased adipose tissue blood flow (ATBF). The present work aimed to analyze possible changes in ATBF with being overweight and menopausal and its putative link to endothelial dysfunction and autonomic nervous system balance. Forty-three healthy women were classified into four groups according to weight and menopause status. The ATBF was measured by xenon washout while fasting and after oral glucose intake. The nitric oxide synthase inhibitor asymmetric dimethylarginine was used as a marker of endothelial function and heart rate variability-estimated autonomic nervous system activity. Fasting ATBF was decreased in both overweight groups (P = 0.044 and P = 0.048) versus normal-weight premenopausal women. Normal-weight and overweight postmenopausal women exhibited lower maximum ATBF compared with normal-weight premenopausal women (P = 0.015 and P = 0.001, respectively), and overweight postmenopausal women exhibited lower maximum ATBF compared with normal-weight postmenopausal women (P = 0.003). A negative correlation was found between fasting ATBF and asymmetric dimethylarginine (P = 0.015), whereas maximum ATBF was neg...Continue Reading

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Citations

Jul 28, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J AnderssonT Olsson
Jul 7, 2011·Circulation·Silvia Corvera, Michael P Czech
May 14, 2011·Journal of Clinical Laboratory Analysis·Hikmet KocakDeniz Esin
Sep 14, 2013·Journal of Clinical Pharmacology·Noboru Toda, Tomio Okamura
Sep 4, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Marie Rodling-WahlströmMagnus Hultin
Jun 1, 2014·Free Radical Biology & Medicine·Brian E Sansbury, Bradford G Hill
Feb 11, 2015·The Canadian Journal of Cardiology·Rajeev K PathakPrashanthan Sanders
Feb 10, 2012·American Journal of Physiology. Endocrinology and Metabolism·Richard SotornikJean-Luc Ardilouze
Mar 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Denise E LackeySean H Adams
May 15, 2015·American Journal of Physiology. Endocrinology and Metabolism·Richard SotorníkJean-Luc Ardilouze

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