PMID: 9440820Jan 24, 1998Paper

Dysregulation of the interleukin-2 receptor alpha- and beta-chain expression in CD4 and CD8 T cells in HIV infection

Cytometry
N Johnson, J M Parkin

Abstract

Peripheral blood mononuclear cells were prepared from human immunodeficiency virus-positive (HIV+) individuals (n = 46) to investigate the expression of both chains of the interleukin-2 receptor. Both qualitative and quantitative changes in expression were observed. Total lymphocyte expression of the IL-2 alpha chain (CD25) was decreased compared with HIV-negative (HIV-) controls. This was due to the decrease in the CD4+ population, which favored expression of this receptor, rather than a decrease in expression, per se. CD8+ lymphocytes expressed the beta chain (CD122) in the absence of the alpha chain. However, a significant increase in the number of peripheral blood CD8+ lymphocytes expressing mainly the beta subunit was observed in HIV+ patients (P = 0.02). This was observed to a similar extent in asymptomatic and symptomatic patients and characterized a subpopulation of T lymphocytes expressing high levels of CD8. Lymphocytes from patients with advanced HIV disease failed to up-regulate both alpha and beta chains in response to mitogenic concentrations of phytohaemagglutanin. However, those cells that were able to up-regulate both of the IL-2 receptors were capable of effective signal transduction through the receptor, incr...Continue Reading

Citations

Aug 11, 2006·Medical Physics·Jiayong YanLawrence H Schwartz
May 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Susan MoirAnthony S Fauci
Apr 23, 2002·Clinical and Experimental Immunology·N Imami, F Gotch
Mar 4, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Russell B FoxallAna E Sousa
Dec 9, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M ClericiS Piconi
Dec 2, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J E BrinchmannA Spurkland

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