Dysregulation of the vascular endothelial growth factor and semaphorin ligand-receptor families in prostate cancer metastasis

BMC Systems Biology
R Joseph Bender, Feilim Mac Gabhann

Abstract

The vascular endothelial growth factor (VEGF) family is central to cancer angiogenesis. However, targeting VEGF as an anti-cancer therapeutic approach has shown success for some tumor types but not others. Here we examine the expression of the expanded VEGF family in prostate cancer, including the Semaphorin (Sema) family members that compete with VEGFs for Neuropilin binding and can themselves have pro- or anti-angiogenic activity. First, we used multivariate statistical methods, including partial least squares and clustering, to examine VEGF/Sema gene expression variability in previously published prostate cancer microarray datasets. We show that unlike some cancers, such as kidney cancer, primary prostate cancer is characterized by both a down-regulation of the pro-angiogenic members of the VEGF family and a down-regulation of anti-angiogenic members of the Sema family. We found pro-lymphangiogenic signatures, including the genes encoding VEGFC and VEGFD, associated with primary tumors that ultimately became aggressive. In contrast to primary prostate tumors, prostate cancer metastases showed increased expression of key pro-angiogenic VEGF family members and further repression of anti-angiogenic class III Sema family members...Continue Reading

References

Dec 24, 2002·Prostate Cancer and Prostatic Diseases·A V BonoR Novario
Sep 27, 2003·European Journal of Clinical Investigation·G J CaineG Y H Lip
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yan Ping YuJian-Hua Luo
Mar 15, 2006·Neoplasia : an International Journal for Oncology Research·Tarek A BismarMark A Rubin
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Jan 2, 2007·PLoS Computational Biology·Feilim Mac Gabhann, Aleksander S Popel
Mar 7, 2007·World Journal of Urology·Christoph W M ReuterArnold Ganser
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James J VredenburghHenry S Friedman
Jul 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrea FontanaGuido Bocci
Aug 29, 2009·World Journal of Urology·Andreas ErbersdoblerAlexander Haese
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lorelei A MucciSteven K Clinton
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Dec 30, 2011·The New England Journal of Medicine·Timothy J PerrenUNKNOWN ICON7 Investigators
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·Gera NeufeldOfra Kessler
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William Kevin KellyEric J Small
Jun 23, 2012·Nature·Catherine S GrassoScott A Tomlins
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Sina Koch, Lena Claesson-Welsh
Aug 23, 2012·Physiological Genomics·Liang-Hui ChuJoel S Bader
Sep 26, 2012·Blood·Marta SegarraGiovanna Tosato
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David C SmithMaha Hussain
Jan 25, 2013·Science Translational Medicine·Martin J AryeeSrinivasan Yegnasubramanian
Mar 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Mar 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Chin-Lee WuW Scott McDougal
May 25, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jamie R SchoenbornMin Fang
Sep 13, 2013·Science Translational Medicine·Shazia IrshadCory Abate-Shen
Dec 11, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Dror MichaelsonIsan Chen

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Citations

Nov 8, 2016·Expert Reviews in Molecular Medicine·Cornelia BraicuIoana Berindan-Neagoe
Oct 11, 2020·International Journal of Molecular Sciences·Indre ValiulyteArunas Kazlauskas
Feb 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bo JiaoHui Xu
Jun 22, 2017·Stem Cell Research·Bruna PalodettoSara Teresinha Olalla Saad

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Datasets Mentioned

BETA
GSE21034
GSE35988
GSE38241
GSE32269

Methods Mentioned

BETA
RNA-Seq
biopsies

Software Mentioned

PLS
Decipher
DA
Oncotype

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