Abstract
One of the two copies of the X chromosome is randomly inactivated in females as a means of dosage compensation. Loss of X chromosome inactivation (XCI) is observed in breast and ovarian cancers, and is frequent in basal-like subtype and BRCA1 mutation-associated breast cancers. We investigated the clinical implications of the loss of XCI in ovarian cancer and the association between the loss of XCI and BRCA1 dysfunction. We used open source data generated by The Cancer Genome Atlas (TCGA) Genome Data Analysis Centers. Ward's hierarchical clustering method was used to classify the methylation status of the X chromosome. We grouped 584 high grade serous ovarian adenocarcinomas (HG-SOA) according to methylation status, loss of heterozygosity and deletion or gain of X chromosome into the following five groups: preserved inactivated X chromosome (Xi) group (n = 175), partial reactivation of Xi group (n = 100), p arm deletion of Xi group (n = 35), q arm deletion of Xi group (n = 44), and two copies of active X group (n = 230). We found four genes (XAGE3, ZNF711, MAGEA4, and ZDHHC15) that were up-regulated by loss of XCI. HG-SOA with loss of XCI showed aggressive behavior (overall survival of partial reactivation of Xi group: HR 1.7, ...Continue Reading
References
Jan 1, 1980·Journal of Surgical Oncology·V BorahD J Jussawalla
Apr 17, 1996·Journal of the National Cancer Institute·P C ChengL Dubeau
Jun 17, 2003·Nature Genetics·Vamsi K MoothaLeif C Groop
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Feb 14, 2006·Cancer Cell·Andrea L RichardsonShridar Ganesan
Mar 15, 2006·Cancer Cell·Koichi SuzukiManuel Perucho
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·S GanesanD M Livingston
Dec 6, 2006·Journal of Cellular Biochemistry·Gayle J PageauJeanne B Lawrence
Mar 6, 2007·Nature Genetics·Michael WeberDirk Schübeler
Mar 14, 2007·Cell·Cuiying XiaoBarbara Panning
Mar 14, 2007·Cell·Daniel P SilverDavid M Livingston
Jul 6, 2007·Nature Reviews. Cancer·Gayle J PageauJeanne B Lawrence
Jul 8, 2008·Médecine sciences : M/S·Sandrine Augui, Edith Heard
Oct 30, 2008·Journal of the National Cancer Institute·Felicity LoseUNKNOWN Australian Ovarian Cancer Study Management Group
Dec 22, 2009·Bioinformatics·Bo LiColin N Dewey
Aug 31, 2010·Nucleic Acids Research·Kai WangJinze Liu
Jan 12, 2011·Nature Biotechnology·James T RobinsonJill P Mesirov
May 27, 2011·Cancer Biology & Therapy·Mohammad Mahdi ForghanifardMohammad Reza Abbaszadegan
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Aug 6, 2011·BMC Bioinformatics·Bo Li, Colin N Dewey
Oct 13, 2011·JAMA : the Journal of the American Medical Association·Da YangWei Zhang
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
Nov 14, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Siranoush ManoukianMonica Miozzo
Feb 19, 2013·Cell·Eda YildirimJeannie T Lee
Dec 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R J Kurman
Citations
Sep 12, 2015·PloS One·Jun KangLee-So Maeng
Sep 28, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irene Cantone, Amanda G Fisher
Feb 13, 2020·Diagnostics·John Lewis EtterKevin H Eng
Feb 16, 2018·PLoS Genetics·Kevin H EngKunle O Odunsi
Jul 28, 2016·Genes, Chromosomes & Cancer·Tiberio SticcaVincent Bours
Aug 4, 2018·Current Medical Science·Chang LiuQing-Mei Zhang
May 27, 2021·Genetics Research·Zhuo SunYufeng Zhao