Dysregulation of Zinc Finger Protein 395 Contributes to the Pathogenesis of Chondrosarcoma.

OncoTargets and Therapy
Changbao ChenXinlong Ma

Abstract

The transcription factor zinc finger protein 395 (ZNF395) is involved in several cellular responses and tumorigenesis. However, the potential role and clinical significance of ZNF395 in chondrosarcoma are not well investigated. This study determines the expression profile, prognostic value and biological function of ZNF395 in human chondrosarcoma. The mRNA and protein expressions of ZNF395 in fresh chondrosarcomas and the matched adjacent non-tumor tissues were assessed using real-time PCR and immunoblotting, respectively. The protein expression of ZNF395 in chondrosarcoma specimens was evaluated by immunohistochemistry, and the relationships among its protein level, clinicopathological parameters and prognosis were further detected. Cell viability, colony formation, migration, invasion and apoptosis assay were evaluated in chondrosarcoma cells with depletion of ZNF395. The mRNA and protein expressions of ZNF395 in chondrosarcoma tissues were significantly higher than those in the matched adjacent non-tumor tissues and benign cartilage tumors. Clinical analysis displayed that ZNF395 was expressed at higher levels in chondrosarcoma patients with higher histological grade and advanced MSTS stage. Furthermore, we demonstrated that...Continue Reading

References

Feb 17, 2001·Current Opinion in Structural Biology·J H LaityP E Wright
Sep 26, 2002·Expert Review of Molecular Diagnostics·Leida B RozemanJudith V M G Bovée
Jan 16, 2003·Nucleic Acids Research·S Sri KrishnaNick V Grishin
May 16, 2006·The Journal of Laboratory and Clinical Medicine·Keith M SkubitzAmy P N Skubitz
May 29, 2007·Archives of Biochemistry and Biophysics·Nadine SichtigGertrud Steger
Jun 19, 2009·PloS One·Anastasia MuratMonika E Hegi
Jul 28, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Changbao ChenQingjun Ma
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Oct 19, 2011·The Journal of Bone and Joint Surgery. American Volume·Changbao ChenQingjun Ma
Dec 17, 2016·Breast Cancer : Basic and Clinical Research·Ryoko OiMasayuki Takagi
Jan 31, 2017·Future Oncology·Genovefa PolychronidouRobin L Jones
Mar 21, 2017·Mediators of Inflammation·Linda SchroederGertrud Steger
May 3, 2019·Histology and Histopathology·Qin YeKe Xie
Sep 4, 2019·Molecular Carcinogenesis·Changbao ChenXinlong Ma
Jun 21, 2020·Journal of Experimental & Clinical Cancer Research : CR·Guoliang SunHua Xu

❮ Previous
Next ❯

Software Mentioned

Cell Quest
SPSS

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.