Dyssynchrony indices to predict response to cardiac resynchronization therapy: a comprehensive prospective single-center study

Circulation. Heart Failure
Chinami MiyazakiJae K Oh

Abstract

Whether mechanical dyssynchrony indices predict reverse remodeling (RR) or clinical response to cardiac resynchronization therapy (CRT) remains controversial. This prospective study evaluated whether echocardiographic dyssynchrony indices predict RR or clinical response after CRT. Of 184 patients with heart failure with anticipated CRT who were prospectively enrolled, 131 with wide QRS and left ventricular ejection fraction <35% had 6-month follow-up after CRT implantation. Fourteen dyssynchrony indices (feasibility) by M-mode (94%), tissue velocity (96%), tissue Doppler strain (92%), 2D speckle strain (65% to 86%), 3D echocardiography (79%), and timing intervals (98%) were evaluated. RR (end-systolic volume reduction ≥15%) occurred in 55% and more frequently in patients without (71%) than in patients with (42%) ischemic cardiomyopathy (P=0.002). Overall, only M-mode, tissue Doppler strain, and total isovolumic time had a receiver operating characteristic area under the curve (AUC) greater than the line of no information, but none of these were strongly predictive of RR (AUC, 0.63 to 0.71). In nonischemic cardiomyopathy, no dyssynchrony index predicted RR. In ischemic cardiomyopathy, M-mode (AUC, 0.67), tissue Doppler strain (A...Continue Reading

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References

Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
Jul 10, 2003·Echocardiography·Scipione CarerjGiuseppe Oreto
Nov 3, 2004·Journal of the American College of Cardiology·Jeroen J BaxMartin J Schalij
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Dec 20, 2005·Journal of the American College of Cardiology·Jeroen J BaxCheuk-Man Yu
Dec 11, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·J van DijkO Kamp
Mar 4, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·John GorcsanUNKNOWN Heart Rhythm Society
May 7, 2008·Circulation·Eugene S ChungJaime Murillo

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Citations

Nov 19, 2011·European Heart Journal Cardiovascular Imaging·Otto A SmisethHelge Skulstad
Jan 10, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Khaled Z Abd-ElmoniemM Roselle Abraham
Dec 24, 2013·Current Heart Failure Reports·Gregory F Egnaczyk, Eugene S Chung
Aug 2, 2014·Progress in Cardiovascular Diseases·Karen Modesto, Partho P Sengupta
Jan 23, 2013·Current Cardiology Reports·Manish Bansal, Partho P Sengupta
Dec 15, 2010·Heart Failure Reviews·Olusegun A OyenugaJohn Gorcsan
Apr 23, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Liselotte M KlitsieArend D J Ten Harkel
Apr 2, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Freddy Del-Carpio MunozSamuel J Asirvatham
Feb 17, 2015·Pacing and Clinical Electrophysiology : PACE·Abdul GhaniArif Elvan
Feb 11, 2015·Heart·Makoto SaitoUNKNOWN Protect-Pace investigators
Feb 23, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Victor Mor-AviJosé Luis Zamorano
Oct 13, 2012·JACC. Cardiovascular Imaging·Sukhjinder S NijjerDarrel P Francis
Jun 24, 2016·Pacing and Clinical Electrophysiology : PACE·Oguz KaracaFethi Kilicaslan
Mar 10, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Victor Mor-AviJose Luis Zamorano
Feb 21, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Rita Ilhão MoreiraMário Martins Oliveira
Nov 28, 2012·Journal of cardiovascular ultrasound·Qing Zhang, Cheuk-Man Yu
Jan 18, 2012·Circulation·Amil M Shah, Scott D Solomon
Sep 16, 2010·Circulation. Heart Failure·Eugene S Chung, Wojciech Mazur
Nov 23, 2011·Circulation·Bernard ThibaultUNKNOWN Evaluation of Resynchronization Therapy for Heart Failure (GREATER-EARTH) Investigators
May 10, 2016·F1000Research·Oana MireaJens-Uwe Voigt
Nov 27, 2019·Expert Review of Cardiovascular Therapy·Andrada C GutaDenisa Muraru
Sep 3, 2013·Current Opinion in Critical Care·Nicole M Bhave, Roberto M Lang
Jul 1, 2014·Journal of Medical Ultrasonics·Chris L de KorteLivia Kapusta
Nov 5, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michael GliksonJae K Oh

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