Dystrophic neuritic processes in epileptic cortex

Epilepsy Research
A R JudkinsJ A Golden

Abstract

Cortical dysplasia is a frequent finding in cortical resections from children with refractory epilepsy. Diagnostic criteria and a classification scheme for cortical dysplasia has been proposed, though the relationship between specific cortical dysplasia features and their causal relationship with epilepsy is poorly understood. We reviewed 28 surgical resections from children and identified a common and easily recognized feature of cortical dysplasia: maloriented, misshapen and occasionally coarse neurofilament stained process forming a dystrophic neuritic background. The dystrophic neuritic background was associated with other features of cortical dysplasia in all 28 patients with cortical dysplasia, 26 with refractory epilepsy and 2 patients with other neurologic diagnoses. In seven children with refractory epilepsy due to other pathologic diagnosis such as vascular or glial lesions, the dystrophic neuritic background was only found in one patient with a ganglioglioma and other features suggestive of an associated cortical dysplasia. Our data indicate that a dystrophic neuritic background is a common and relatively specific neuropathologic finding in cortical dysplasia.

References

Mar 1, 1992·Epilepsia·M DuchownyP Dean
Sep 1, 1989·Annals of Neurology·T SutulaL Ramirez
Aug 1, 1971·Journal of Neurology, Neurosurgery, and Psychiatry·D C TaylorJ A Corsellis
Mar 1, 1995·Journal of Neuropathology and Experimental Neurology·P S MischelH V Vinters
Jan 1, 1994·Acta Neuropathologica·T DuongR S Fisher
Jul 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·S HirabayashiC E Polkey
Dec 1, 1996·Journal of Neuropathology and Experimental Neurology·A Kendler, J A Golden
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·C NordborgK Malmgren
Feb 19, 2000·Neurology·J M PaolicchiM Duchowny
May 29, 2000·Brain : a Journal of Neurology·S M Sisodiya
Jul 24, 2002·Brain : a Journal of Neurology·L TassiR Spreafico
Mar 24, 2004·Neurology·A PalminiH V Vinters

❮ Previous
Next ❯

Citations

Dec 29, 2020·Frontiers in Aging Neuroscience·Yan-Bin ShiXiao-Xin Yan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Body Dysmorphic Disorder

Body dysmorphic disorder is an intense preoccupation with an imagined defect in ones physical appearance. It can be a severely impairing disorder and is common among patients with obsessive-compulsive disorder. Discover the latest research on body dysmorphic disorder here.