PMID: 2497927Mar 6, 1989Paper

Dystrophic peptidergic neurites in senile plaques of Alzheimer's disease hippocampus precede formation of paired helical filaments

Brain Research
M B LendersM Mazzuca

Abstract

The relationship between peptidergic dystrophic neurites and paired helical filament (PHF)-positive neurites in Alzheimer's disease (AD) senile plaques (SPs) was studied using combined fluorescence and bright-field optics. Cryostat sections of AD hippocampi were first stained with thioflavine-S and immunolabelled with antisera raised against different neuropeptides: somatostatin-28(1-12), somatostatin-14, neuropeptide Y, cholecystokinin (CCK) and substance P. Secondly, using the elution-restaining procedure, sections were immunolabelled with anti-tau/PHF. In immature SPs, clusters of abnormal, swollen neurites were found. The dystrophic, strongly peptidic-positive neurites contained fewer PHFs than the poorly positive ones. Cell bodies, exhibiting a peptidic content, could be found within SPs without any alteration. These results suggest the following sequence of events: an extracellular poisoning mechanism, perhaps the amyloid substance, first changes the structure of presynaptic endings and causes the formation of ballooning dystrophic neurites filled with their normal peptidic content. Subsequently, intracellular degradation occurs with formation of the PHFs. Then the other structures such as dendrites and perikarya are dama...Continue Reading

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Citations

Jan 1, 1994·Acta Neuropathologica·J P Brion, A Résibois
May 1, 1993·Neurobiology of Aging·M K CarpenterS B Kater
Jul 31, 2012·Human Molecular Genetics·Elizabeth M RodriguesLawrence S B Goldstein
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qi ShiRiqiang Yan
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
Aug 8, 2015·Anatomia, histologia, embryologia·M L SánchezR Coveñas

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