PMID: 2123804Nov 12, 1990Paper

Dystrophin as a focal adhesion protein. Collocalization with talin and the Mr 48,000 sarcolemmal protein in cultured Xenopus muscle

FEBS Letters
N R Kramarcy, R Sealock

Abstract

Monoclonal antibodies against dystrophin and the postsynaptic 58 kDa protein from Torpedo electric organ were used to localize homologs of these proteins in cultured skeletal muscle (Xenopus laevis). The Xenopus homolog is an Mr 48,000 protein and, like dystrophin, is a sarcolemmal protein. Both proteins localized precisely to talin-positive sites, hence with each other, on the substrate-apposed sarcolemma. Therefore, the first sites of appearance of dystrophin on cultured muscle cells are focal adhesions, i.e. specific sites of cytoskeleton/extracellular matrix interaction. These data also add to evidence that dystrophin and the 58 kDa act together.

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Citations

Apr 1, 1993·Nature Genetics·A H Ahn, L M Kunkel
Mar 1, 1994·Cancer Metastasis Reviews·S H Lo, L B Chen
Jan 1, 1996·Cell Motility and the Cytoskeleton·M JamesG E Morris
Jun 29, 2006·British Journal of Haematology·Doris CerecedoAlvaro Rendón
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Jan 11, 2001·Muscle & Nerve·J Kong, J E Anderson
Jan 1, 1994·Cell Motility and the Cytoskeleton·P W LutherR J Bloch
Jun 9, 1997·Biochemical and Biophysical Research Communications·L LiuE Engvall
Apr 7, 2000·Brain Research. Brain Research Reviews·M F Mehler
Oct 1, 1991·Current Opinion in Cell Biology·C E Turner, K Burridge
Feb 1, 1994·Current Opinion in Cell Biology·A L Hitt, E J Luna

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