Dystrophin deficiency reduces atherosclerotic plaque development in ApoE-null mice

Scientific Reports
Annelie ShamiA Hultgårdh-Nilsson

Abstract

Dystrophin of the dystrophin-glycoprotein complex connects the actin cytoskeleton to basement membranes and loss of dystrophin results in Duchenne muscular dystrophy. We have previously shown injury-induced neointima formation of the carotid artery in mice with the mdx mutation (causing dystrophin deficiency) to be increased. To investigate the role of dystrophin in intimal recruitment of smooth muscle cells (SMCs) that maintains plaque stability in atherosclerosis we applied a shear stress-modifying cast around the carotid artery of apolipoprotein E (ApoE)-null mice with and without the mdx mutation. The cast induces formation of atherosclerotic plaques of inflammatory and SMC-rich/fibrous phenotypes in regions of low and oscillatory shear stress, respectively. Unexpectedly, presence of the mdx mutation markedly reduced the development of the inflammatory low shear stress plaques. Further characterization of the low shear stress plaques in ApoE-null mdx mice demonstrated reduced infiltration of CD3(+) T cells, less laminin and a higher SMC content. ApoE-null mdx mice were also found to have a reduced fraction of CD3(+) T cells in the spleen and lower levels of cytokines and monocytes in the circulation. The present study is th...Continue Reading

References

Jan 1, 1991·Neuromuscular Disorders : NMD·A E Emery
Nov 1, 1990·Journal of Biochemistry·M Yoshida, E Ozawa
Mar 16, 1989·Nature·K P Campbell, S D Kahl
Jul 1, 1988·Neuron·E P HoffmanL M Kunkel
Nov 1, 1984·Muscle & Nerve·J Dangain, G Vrbova
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G BulfieldK J Moore
Nov 1, 1981·Atherosclerosis·J H Chamley-Campbell, G R Campbell
Aug 1, 1993·The Journal of Cell Biology·J M Ervasti, K P Campbell
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B J PetrofH L Sweeney
Jun 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J ThybergU Hedin
Oct 26, 2000·Current Opinion in Lipidology·A Chait, T N Wight
Dec 12, 2001·Cardiovascular Research·E P Moiseeva
Mar 7, 2002·Lancet·Alan E H Emery
Jun 17, 2006·Human Molecular Genetics·Kaori ItoTeruhisa Miike
Dec 13, 2006·Pediatric Neurology·Nicolas Deconinck, Bernard Dan
May 26, 2007·Journal of Applied Physiology·W W DyeJ D Humphrey
Aug 4, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Elena Galkina, Klaus Ley
Sep 27, 2007·Experimental Biology and Medicine·Valerie S LeBleuRaghu Kalluri
Jan 4, 2008·American Journal of Physiology. Cell Physiology·Dennis R Claflin, Susan V Brooks
May 10, 2008·The American Journal of Pathology·Stephanie SchultePeter Libby
Jan 16, 2009·Vascular Medicine·Eser AdiguzelMichelle P Bendeck
May 20, 2009·The Journal of Clinical Investigation·Sylvia A VetroneMelissa J Spencer
Dec 16, 2010·Neuropathology and Applied Neurobiology·M C Dalakas
Jan 13, 2012·PloS One·Uwe RauchAnna Hultgårdh-Nilsson
Mar 13, 2012·Cardiovascular Research·Delphine Gomez, Gary K Owens
Dec 4, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Annelie ShamiAnna Hultgårdh-Nilsson
May 6, 2014·Nature Genetics·Yuexiang WangJonathan A Fletcher

❮ Previous
Next ❯

Citations

Dec 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philip TannenbergKarin Tran-Lundmark
Aug 3, 2017·Journal of Vascular Research·Vignesh MurugesanUwe Rauch
Dec 15, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Bruce A CorlissShayn M Peirce

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

BioPix iQ
Summit
GraphPad
GraphPad Prism

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.