E-cadherin as a predictive marker of brain metastasis in non-small-cell lung cancer, and its regulation by pioglitazone in a preclinical model.

Journal of Neuro-oncology
Jin Young YooSang Won Lee

Abstract

It remains unclear whether patients with non-small-cell lung cancer (NSCLC) develop brain metastasis during or after standard therapy. We attempted to identify biological markers that predict brain metastasis, and investigated how to modulate expression of such markers. A case-control study of patients who were newly diagnosed with NSCLC and who had developed brain metastasis during follow-up was conducted between 2004 and 2009. These patients were compared with a control group of patients who had NSCLC but no evidence of brain metastasis. Immunohistochemical analysis of expression of Ki-67, p53, Bcl-2, Bax, vascular endothelial growth factor, epidermal growth factor receptor, caspase-3, and E-cadherin was conducted. The methylation status of the genes for O(6)-methylguanine-DNA-methyltransferase, tissue inhibitor of matrix metalloproteinase (TIMP)-2, TIMP-3, and death-associated protein-kinase was also determined, by use of a methylation-specific polymerase chain reaction. A significantly increased risk of developing brain metastasis was associated with the presence of primary tumors with low E-cadherin expression in patients with NSCLC. We also investigated the effects of pioglitazone, a peroxisome proliferator-activated rece...Continue Reading

References

Aug 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S LeeW K Hong
Jul 8, 2000·Brain Pathology·I PetersenA von Deimling
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J RobnettS M Hahn
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R I NicholsonM E Harper
Oct 18, 2001·The Annals of Thoracic Surgery·T A D'AmicoD H Harpole
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Robbin S BubbLuka Milas
Nov 8, 2003·Brain Tumor Pathology·Hamisi Kimaro ShabaniMasachika Iseki
May 26, 2006·Histopathology·F B J M ThunnissenM A den Bakker
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa D YeeCharis Eng
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rangaswamy GovindarajanNicholas P Lang
Nov 3, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Raphael A Nemenoff
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tom DonnemRoy M Bremnes
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
May 17, 2008·Cancer Research·Tamer T OnderRobert A Weinberg
Jun 3, 2008·Neoplasia : an International Journal for Oncology Research·Raju C ReddyVenkateshwar G Keshamouni
Jun 6, 2008·PPAR Research·Masahito Shimizu, Hisataka Moriwaki
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Geoffrey D GirnunKwok-Kin Wong
Jan 27, 2009·Cancer Metastasis Reviews·Mahmut Yilmaz, Gerhard Christofori
Mar 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ludmila PrudkinIgnacio I Wistuba
Apr 28, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Asish K GhoshJohn Varga
Oct 29, 2009·Carcinogenesis·Christopher M LyonSteven A Belinsky
Mar 18, 2010·Neoplasia : an International Journal for Oncology Research·Rashmi ChoudharyRaphael A Nemenoff

❮ Previous
Next ❯

Citations

Sep 29, 2019·Journal of Neurosurgery·Ho Jun YiSeung Ho Yang
Jan 25, 2013·International Journal of Molecular Sciences·Imola WilhelmIstván A Krizbai
Sep 30, 2014·The Journal of Medical Investigation : JMI·Masaki HanibuchiYasuhiko Nishioka
Feb 16, 2018·American Journal of Respiratory Cell and Molecular Biology·Kerstin W SinkeviciusCarla F Kim
Dec 29, 2013·Clinical & Experimental Metastasis·Juan P RodrigoJuana María García-Pedrero
Mar 29, 2016·Cancer Metastasis Reviews·Helmut H Popper
May 17, 2014·The International Journal of Biological Markers·Qian Huang, Xuenong Ouyang
Sep 19, 2017·Cellular Oncology (Dordrecht)·Meysam YousefiSeyed H Ghaffari
Feb 5, 2021·Frontiers in Oncology·Yalin KangXianglin Yuan

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.