Abstract
Abnormal exposure of acid refluxate on the esophageal mucosa has been shown to decrease the epithelial barrier function through an alteration in the intercellular junctional complex. However, only few studies have examined the molecular effects caused by abnormal exposure of gastric refluxate on the laryngeal epithelium. E-cadherin and beta-catenin are cell membrane-associated proteins playing a major role in the maintenance of cell-cell adhesion in epithelial tissues. In this study we tried to analyse the molecular effect of laryngopharyngeal reflux (LPR) on the cellular expression of these proteins. Therefore, we compared the expression of E-caherin and beta-catenin in laryngeal biopsies from patients with and without pH-documented laryngopharyngeal reflux. Paraffin-embedded archival laryngeal biopsies taken from 21 patients, who had undergone rigid laryngoscopy under general anaesthesia and postoperative 24-h pH monitoring, were evaluated immunohistochemically with antibodies to E-cadherin and beta-catenin. The membrane expression of the two proteins was categorized in no expression, mild, moderate and strong (grade 0-3). In LPR patients (n=14) the mean grade of E-cadherin and beta-catenin expression was 1.57 and 1.21, while...Continue Reading
References
Mar 1, 1995·British Journal of Cancer·S DorudiI R Hart
Oct 1, 1993·Current Opinion in Cell Biology·M Takeichi
Oct 21, 1993·International Journal of Cancer. Journal International Du Cancer·V MattijssenD J Ruiter
Nov 1, 1995·European Journal of Gastroenterology & Hepatology·A I LanasR Sáinz
Jun 21, 1996·International Journal of Cancer. Journal International Du Cancer·H E GabbertG Hommel
Mar 1, 1997·Gastroenterology·N A TobeyR C Orlando
Mar 1, 1997·Oncology·Y NakanishiS Hirohashi
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M LiuM Remacle
Dec 31, 1998·Gastroenterology·A LanasR Sáinz
Jun 30, 2000·Journal of Voice : Official Journal of the Voice Foundation·D A VincentC R Stasney
Sep 25, 2001·The Laryngoscope·P C BelafskyJ A Koufman
Nov 28, 2001·The American Journal of Gastroenterology·N A TobeyR C Orlando
Aug 2, 2002·Journal of Voice : Official Journal of the Voice Foundation·Peter C BelafskyJames A Koufman
Jul 2, 2003·The Annals of Otology, Rhinology, and Laryngology·Nikki JohnstonJames A Koufman
Oct 28, 2005·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Samet OzlugedikKursat Gokcan
Nov 29, 2005·Journal of Clinical Pathology·G A GillM Pignatelli
Jan 10, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kevin A KurtzRobert A Robinson
Sep 2, 2006·The American Journal of Medicine·Michael F VaeziNatalie Colabianchi
Feb 6, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Oliver ReichelAlexander Berghaus
Feb 1, 2004·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Na-Hye Myong
Citations
Jun 22, 2010·HNO·K J LorenzH Maier
Jan 26, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mahalakshmi SivasankarRyan C Branski
Sep 15, 2011·The Journal of Laryngology and Otology·J M WoodA S Carney
May 31, 2012·Journal of Oncology·Thian-Sze WongWai-Kuen Ho
Dec 15, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kai J LorenzH Maier
Dec 18, 2014·HNO·K J LorenzK Steinestel
Nov 19, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kai J Lorenz
Jan 1, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Elizabeth A KellyNikki Johnston
Apr 2, 2014·Journal of Speech, Language, and Hearing Research : JSLHR·Elizabeth Erickson LevendoskiSusan L Thibeault
Mar 21, 2019·The Laryngoscope·Jerome R LechienLee M Akst
Jan 29, 2011·The Laryngoscope·Bernard RousseauMahalakshmi Sivasankar
Jul 22, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ya-Lian ChenZhe Chen
Aug 1, 2020·PloS One·Naila Cannes do NascimentoAbigail Cox
Oct 19, 2017·The Laryngoscope·Byoungjae KimTae Hoon Kim
Apr 3, 2019·Cancer Cell International·Jia-Jie TanXiang-Ping Li
Jan 16, 2021·Journal of Inflammation Research·Danling LiuJack J Jiang
Nov 28, 2020·American Journal of Otolaryngology·Jerome R LechienSven Saussez
Dec 5, 2020·American Journal of Otolaryngology·Xiang-Ping LiZe-Hong Lv
Nov 7, 2020·The Laryngoscope·Gary J GartlingBernard Rousseau
Aug 1, 2020·Clinical and Experimental Otorhinolaryngology·Cheng-Yi YinShui-Hong Zhou
Jun 3, 2021·Microorganisms·Li-Jen HsinLi-Ang Lee