E-Cadherin/β-Catenin Complex: A Target for Anticancer and Antimetastasis Plants/Plant-derived Compounds

Nutrition and Cancer
Majid Tafrihi, Roohollah Nakhaei Sistani

Abstract

Plants reputed to have cancer-inhibiting potential and putative active components derived from those plants have emerged as an exciting new field in cancer study. Some of these compounds have cancer-inhibiting potential in different clinical staging levels, especially metastasis. A few of them which stabilize cell-cell adhesions are controversial topics. This review article introduces some effective herbal compounds that target E-cadherin/β-catenin protein complex. In this article, at first, we briefly review the structure and function of E-cadherin and β-catenin proteins, Wnt signaling pathway, and its target genes. Then, effective compounds of the Teucrium persicum, Teucrium polium, Allium sativum (garlic), Glycine max (soy), and Brassica oleracea (broccoli) plants, which influence stability and cellular localization of E-cadherin/β-catenin complex, were studied. Based on literature review, there are some compounds in these plants, including genistein of soy, sulforaphane of broccoli, organosulfur compounds of garlic, and the total extract of Teucrium genus that change the expression of variety of Wnt target genes such as MMPs, E-cadherin, p21, p53, c-myc, and cyclin D1. So they may induce cell-cycle arrest, apoptosis and/or ...Continue Reading

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Citations

Jun 6, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Waisheng ZhongJie Chen
Nov 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Prabhakaran Soundararajan, Jung Sun Kim
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Feb 17, 2021·Journal of Translational Medicine·Jinxiu HuZhimei Lv
Aug 30, 2021·European Journal of Pharmacology·Mohammad PiryaeiMohammad Amin Javidi

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Methods Mentioned

BETA
glycosylation
ubiquitination
nuclear translocation
xenograft
PCR
histone acetylation

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