PMID: 11342899May 9, 2001Paper

E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup

The Journal of Urology
R R ByrneSeth P Lerner

Abstract

We analyze the expression of E-cadherin in bladder transitional cell carcinoma, areas of carcinoma in situ and lymph node metastases, and determine the value of E-cadherin immunoreactivity for predicting disease progression and survival of patients with bladder transitional cell carcinoma. The study group consisted of 77 patients who underwent radical cystectomy. Formalin fixed paraffin sections were processed with a hot, citric acid antigen retrieval method, followed by immunostaining with anti-E-cadherin monoclonal antibody and a standard avidin biotin complex technique. E-cadherin expression was also evaluated in carcinoma in situ sections (18) and in regional lymph node metastases (17). Loss of normal membrane E-cadherin immunoreactivity was found in 59 (77%) patients. Abnormal expression of E-cadherin was associated with muscle invasive disease (p = 0.010) and lymph node metastasis (p = 0.044). Of the 18 carcinoma in situ specimens 15 (83%) and of the 17 metastatic lymph nodes 13 (76%) had abnormal E-cadherin expression. Concordance rates of E-cadherin status in carcinoma in situ areas and metastatic lymph nodes with the primary tumors were 85% and 88%, respectively. At a median followup of 128 months, abnormal E-cadherin ...Continue Reading

References

Apr 1, 1991·The Journal of Cell Biology·U H FrixenW Birchmeier
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·P K Lipponen, M J Eskelinen
Oct 16, 1999·International Journal of Cancer. Journal International Du Cancer·P P BringuierJ A Schalken
Nov 1, 1992·The Australian and New Zealand Journal of Surgery·F T McDermott

❮ Previous
Next ❯

Citations

Apr 22, 2003·Pathology Oncology Research : POR·Yeung NgN Waterfall
Oct 26, 2006·World Journal of Urology·Christopher Y Thomas, Dan Theodorescu
Feb 23, 2012·Current Urology Reports·Michael RinkShahrokh F Shariat
Jan 17, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P WangY R Huang
Sep 8, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Matthew G LimAdeboye O Osunkoya
Feb 18, 2004·Nature Reviews. Cancer·Ugo Cavallaro, Gerhard Christofori
Mar 29, 2006·Journal of Clinical Pathology·L Kanczuga-KodaM Sulkowska
Oct 9, 2008·Annual Review of Pathology·Anirban P Mitra, Richard J Cote
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Feb 28, 2004·Diabetes Care·Márta UjpálZsuzsanna Suba
Dec 18, 2013·Urologic Oncology·Evanguelos XylinasShahrokh F Shariat
Mar 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongshuo ZhangBo Fan
May 26, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·B BrunettiC Benazzi
Aug 31, 2002·Molecular Carcinogenesis·Leopoldo Alves Ribeiro-FilhoRajvir Dahiya
Feb 14, 2006·Cancer·Paulette Mhawech-FaucegliaJuerg Schwaller
Sep 30, 2010·International Journal of Cancer. Journal International Du Cancer·Bastian KeckArndt Hartmann
Sep 7, 2018·Current Opinion in Urology·Andreas BruchbacherDavid D'Andrea
Apr 18, 2007·Cell Biochemistry and Function·Ke ZhangYuhang Liu
Oct 3, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Ofer NativMoshe Aronson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.