E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
T OsadaS Hirohashi

Abstract

In human hepatocellular carcinoma (HCC), the liver is the major target organ of metastasis, which is known as intrahepatic metastasis. To analyze the mechanism of this metastasis, we established two sublines from the human HCC cell line Li7. Subline Li7HM produced multiple liver metastasis, whereas subline Li7NM never did so after intrasplenic injection into nude mice. Two-dimensional gel electrophoresis and immunoblot analysis showed that only Li7NM expressed vimentin and lacked E-cadherin expression, indicating that this clone had undergone epithelial-mesenchymal transition. We then transfected mouse E-cadherin complementary DNA into Li7NM cells and found that the transfectant cells (EM16.21B.3) formed liver metastasis (8/16 mice) after intrasplenic injection and liver tumors (11/13 mice) after intrahepatic injection, whereas the control cell line formed no tumors. These results suggest that E-cadherin plays an important role in the process of intrahepatic metastasis of HCC.

Citations

Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·S KuriyamaH Fukui
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T GendaS Hirohashi
Oct 7, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Peter J KneuertzTimothy M Pawlik
Feb 14, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zu-hua GaoJohn Hart
Aug 9, 2002·Journal of Gastroenterology and Hepatology·Tetsuya SuzukiMasamichi Kojiro
Oct 11, 2003·Journal of Gastroenterology and Hepatology·Kengo KanetakaSetsuo Hirohashi
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OkabeY Yamaoka
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yu WeiMarie-Annick Buendia
Apr 6, 2011·Cancer Research·Alla ArzumanyanMark A Feitelson
Jul 3, 2008·World Journal of Gastroenterology : WJG·Bo ZhaiHong-Yang Wang
Oct 7, 2008·World Journal of Gastroenterology : WJG·Bo ZhaiHong-Yang Wang
Feb 3, 2007·The Journal of Surgical Research·Yukihiro HigashiHiroyuki Konno
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiya YamamotoSetsuo Hirohashi
Jul 11, 2006·Journal of Cellular Physiology·Carla CicchiniMarco Tripodi
Nov 22, 2005·Journal of Surgical Oncology·Zu-Hua Gao
Jun 10, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takao MamiyaMichiie Sakamoto
May 28, 2021·Arkhiv patologii·N V DanilovaP G Malkov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.