E-cadherin is required for cranial neural crest migration in Xenopus laevis

Developmental Biology
Chaolie HuangJubin Kashef

Abstract

The cranial neural crest (CNC) is a highly motile and multipotent embryonic cell population, which migrates directionally on defined routes throughout the embryo, contributing to facial structures including cartilage, bone and ganglia. Cadherin-mediated cell-cell adhesion is known to play a crucial role in the directional migration of CNC cells. However, migrating CNC co-express different cadherin subtypes, and their individual roles have yet to be fully explored. In previous studies, the expression of individual cadherin subtypes has been analysed using different methods with varying sensitivities, preventing the direct comparison of expression levels. Here, we provide the first comprehensive and comparative analysis of the expression of six cadherin superfamily members during different phases of CNC cell migration in Xenopus. By applying a quantitative RT-qPCR approach, we can determine the copy number and abundance of each expressed cadherin through different phases of CNC migration. Using this approach, we show for the first time expression of E-cadherin and XB/C-cadherin in CNC cells, adding them as two new members of cadherins co-expressed during CNC migration. Cadherin co-expression during CNC migration in Xenopus, in pa...Continue Reading

References

Feb 1, 1987·Developmental Biology·S A Moody
Sep 1, 1994·Mechanisms of Development·H A MüllerD Wedlich
Oct 1, 1995·Current Opinion in Cell Biology·M Takeichi
Oct 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Kühl, D Wedlich
May 12, 1998·Mechanisms of Development·B HadeballD Wedlich
Nov 10, 1998·Developmental Biology·C Hensey, J Gautier
Feb 11, 1999·The Journal of Cell Biology·P NiewiadomskaU Tepass
Feb 9, 2000·The Journal of Cell Biology·B M Gumbiner
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C G KleerS D Merajver
Jan 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ting LuoThomas D Sargent
Jun 7, 2003·Developmental Cell·Amy BellmeyerCarole LaBonne
Aug 19, 2003·Developmental Biology·Dominique AlfandariDouglas W DeSimone
Sep 6, 2003·Journal of Immunological Methods·Joseph A WhelanMichael A Whelan
Oct 29, 2003·Breast Cancer Research : BCR·Paul J KowalskiCelina G Kleer
Nov 19, 2003·Mechanisms of Development·David Shook, Ray Keller
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·James A WestonShinichi Nishikawa
Apr 29, 2005·Development·Jaime De CalistoRoberto Mayor
Oct 14, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mireille BaltzingerFilippo M Rijli
Dec 13, 2006·Genes & Development·Jennifer M Halbleib, W James Nelson
Nov 16, 2007·Breast Cancer Research : BCR·Joana ParedesFernando C Schmitt
Jun 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marie Anne BreauJames A Weston
Aug 19, 2008·Molecular Cancer Research : MCR·Khoi ChuSue-Hwa Lin
Nov 13, 2008·Genesis : the Journal of Genetics and Development·Tatjana Sauka-Spengler, Marianne Bronner-Fraser
Jun 24, 2009·Nature Reviews. Molecular Cell Biology·Peter Friedl, Darren Gilmour
Dec 17, 2009·Nature Cell Biology·Elena KardashErez Raz
May 1, 2010·Journal of Cellular Physiology·Rajalakshmanan EswaramoorthyChau-Zen Wang
May 28, 2010·Cell Adhesion & Migration·Dominque AlfandariMungo Marsden
Jul 21, 2010·Developmental Cell·Eric TheveneauRoberto Mayor
Jul 19, 2011·Developmental Cell·Masatoshi Takeichi
Dec 17, 2011·Current Opinion in Cell Biology·Vanessa Barone, Carl-Philipp Heisenberg
Mar 6, 2012·Archives of Biochemistry and Biophysics·Sarah F BeckerJubin Kashef
Jun 12, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alwyn DadyJean-Loup Duband
Aug 22, 2012·The Journal of Cell Biology·Bianca KraftDoris Wedlich
Aug 28, 2012·Science·Jean-Léon MaîtreCarl-Philipp Heisenberg
Jun 19, 2013·Nature Cell Biology·Eric TheveneauRoberto Mayor

❮ Previous
Next ❯

Citations

Mar 3, 2017·Genesis : the Journal of Genetics and Development·Lisa A Taneyhill, Andrew T Schiffmacher
May 6, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alwyn Dady, Jean-Loup Duband
Apr 21, 2018·Genesis : the Journal of Genetics and Development·Nadège GouignardEric Theveneau
Feb 25, 2018·Genesis : the Journal of Genetics and Development·Dominique Alfandari, Lisa A Taneyhill
Aug 7, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Taylor GarmonShuyi Nie
Apr 23, 2019·PLoS Computational Biology·András SzabóRoberto Mayor
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrew T PlygawkoKyra Campbell
Dec 15, 2018·Genesis : the Journal of Genetics and Development·Abigail A Kindberg, Jeffrey O Bush
Aug 8, 2017·Tissue Barriers·Natalya A GloushankovaIrina Y Zhitnyak
Dec 21, 2018·International Journal of Molecular Medicine·Hyun-Kyung LeeHyun-Shik Lee
Nov 17, 2020·Frontiers in Physiology·Subrajaa ManoharCrystal D Rogers
Jan 9, 2021·Neurotoxicology and Teratology·Mariliza Cristine Vieira da CostaClaudia Feijó Ortolani-Machado
Dec 17, 2020·Frontiers in Physiology·Elias H Barriga, Eric Theveneau
Oct 25, 2020·International Journal of Molecular Sciences·Bi Ning ZhangWai Kit Chu
Feb 6, 2019·Developmental Biology·Kamil AhsanVictoria E Prince
Apr 15, 2019·Experimental Eye Research·Surabhi SonamJonathan J Henry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.