PMID: 8601315Mar 22, 1996Paper

E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells

Cell
J MengaudPascale Cossart

Abstract

We report the first identification of a cellular receptor mediating entry of a gram-positive bacterium into nonphagocytotic cells. By an affinity chromatography approach, we identified E-cadherin as the ligand for internalin, an L. monocytogenes protein essential for entry into epithelial cells. Expression of the chicken homolog of E-cadherin (L-CAM) in transfected fibroblasts dramatically increases entry of L. monocytogenes and promotes that of a recombinant L. innocua strain expressing internalin but does not promote entry of the wild-type noninvasive L. innocua or that of an internalin-deficient mutant of L. monocytogenes. Furthermore, L-CAM-specific antibodies block internalin-mediated entry. In contrast to Salmonella, Listeria enters cells by a mechanism of induced phagocytosis occurring without membrane ruffling. This work reveals a novel type of heterophilic interactions for E-cadherin.

References

Jan 1, 1977·Scandinavian Journal of Immunology·G Kaplan
Nov 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Y Pouliot
Jan 1, 1992·Annual Review of Cell Biology·B Geiger, O Ayalon
Jan 1, 1992·Annual Review of Cell Biology·S FalkowD A Portnoy
Jan 1, 1990·Annual Review of Biochemistry·M Takeichi
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
May 1, 1990·Developmental Biology·O W BlaschukY Pouliot
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M OzawaR Kemler
Jun 1, 1985·The Journal of Experimental Medicine·V A FischettiJ R Scott
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R M MegeG M Edelman
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R R Isberg, J M Leong
Jan 27, 1983·The New England Journal of Medicine·W F SchlechC V Broome
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J GallinB A Cunningham
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G M EdelmanJ P Thiery
May 1, 1980·Infection and Immunity·T T MacDonald, P B Carter
Feb 1, 1995·Current Opinion in Genetics & Development·C Kirkpatrick, M Peifer
Oct 1, 1994·Trends in Biochemical Sciences·B Kobe, J Deisenhofer
Mar 23, 1995·Nature·L ShapiroW A Hendrickson
Sep 1, 1993·Molecular Microbiology·S DramsiP Cossart
Jan 1, 1994·Methods in Enzymology·J L GaillardP Cossart
Jan 1, 1994·Trends in Microbiology·R R Isberg, G Tran Van Nhieu

❮ Previous
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Citations

Jan 1, 1997·Cell Motility and the Cytoskeleton·M SandigC H Siu
Mar 14, 2002·Journal of Cellular Biochemistry·Alejandro Peralta SolerKaren A Knudsen
Oct 14, 2004·Journal of Cancer Research and Clinical Oncology·Maria José OliveiraAncy Leroy
Feb 22, 2012·Cancer Metastasis Reviews·Luis A AparicioAngélica Figueroa
Sep 19, 2001·Current Gastroenterology Reports·A NusratA Neish
Mar 24, 2004·Current Opinion in Cell Biology·Roger VogelmannW James Nelson
Apr 15, 2004·Current Opinion in Biotechnology·Willem M de VosMichiel Kleerebezem
Apr 6, 2004·Comptes rendus biologies·Javier Pizarro-CerdáPascale Cossart
Jan 24, 2004·Microbes and Infection·Mischo KursarHans Willi Mittrücker
Jan 24, 2004·Microbes and Infection·Hartmut H NiemannDirk W Heinz
Oct 23, 2013·Microbes and Infection·Olivier Disson, Marc Lecuit
Oct 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·C L Sears
Nov 10, 2000·Advanced Drug Delivery Reviews·R J Parkes, S L Hart
Apr 26, 2000·FEMS Microbiology Letters·J H ParkB S Yoon
Nov 5, 1997·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·P J Sansonetti
Aug 7, 2003·Microbial Pathogenesis·Blanca Estela García-PérezJulieta Luna-Herrera
Apr 6, 2002·FEMS Immunology and Medical Microbiology·Marina CerquettiPaola Mastrantonio
Jan 13, 2001·Current Opinion in Immunology·J Pieters
Jan 13, 2001·Current Opinion in Immunology·P Cossart, H Bierne
Jan 16, 2002·Current Opinion in Immunology·Steven Greenberg, Sergio Grinstein
Jan 17, 2002·Current Opinion in Cell Biology·Patricia J Renfranz, Mary C Beckerle
Feb 1, 1997·Current Opinion in Cell Biology·S Higley, M Way
Apr 30, 1998·Current Opinion in Cell Biology·K Ireton, P Cossart
Mar 10, 2001·Trends in Microbiology·P Cossart
Mar 3, 1998·Trends in Microbiology·M Kuhn, W Goebel
Jan 1, 1997·The Veterinary Journal·J McLauchlin
Aug 30, 2000·Microbes and Infection·T LauwaetA Leroy
Aug 24, 2000·Microbes and Infection·L Braun, P Cossart
Jun 22, 2001·Microbes and Infection·J A Vázquez-BolandW Goebel
May 10, 2003·Microbes and Infection·Ralph Panstruga, Paul Schulze-Lefert
Jun 6, 2003·Microbes and Infection·Daniel F Balkovetz, Jannet Katz
Feb 19, 2000·Current Opinion in Microbiology·E T Harvill, J F Miller
Nov 8, 2002·Trends in Molecular Medicine·Marc Lecuit, Pascale Cossart
Feb 2, 2010·Expert Reviews in Molecular Medicine·Allison H Bartlett, Pyong Woo Park
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·L A KnodlerB B Finlay

❮ Previous
Next ❯

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