E-cadherin mediated adhesion system in cancer cells

Cancer
H ShiozakiM Monden

Abstract

Cadherins are the family of functionally related transmembrane glycoproteins responsible for the Ca(2+)-dependent cell-cell adhesion mechanism that is crucial for the mutual association of vertebrate cells. Because cell dissociation and acquisition of cell motility occur in cancer invasion and metastasis, it is important to study the possible involvement of mutual cell adhesion of cancer cells. The results and observations reported in the literature on the involvement of cadherin-mediated adhesion in the behavior of cancer cells are reviewed and compared with the authors' experimental and clinical studies. In the initial studies, E-cadherin and alpha-catenin or beta-catenin expression have been investigated immunohistochemically. Although these molecules showed strong expression in noncancerous epithelial tissues without exception, the reduction of the immunoreactivities of cancer cells has been observed. These observations suggest that the impaired E-cadherin mediated adhesion system is a characteristic of cells with malignant transformation. The impaired expression of E-cadherin is frequently observed in tumors with aggressive histopathologic characteristics that are defined by morphologic degree of invasiveness and metastasi...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y MiyoshiG Petersen
Oct 1, 1992·Current Opinion in Cell Biology·S TsukitaS Yonemura
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·H OkaS Hirano
Sep 16, 1991·Biochemical and Biophysical Research Communications·A TakadaR Kannagi
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J BehrensW Birchmeier
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K HerrenknechtR Kemler
Apr 1, 1991·The Journal of Cell Biology·U H FrixenW Birchmeier
Apr 1, 1991·International Journal of Cancer. Journal International Du Cancer·M M MareelF M Van Roy
Nov 1, 1990·The Journal of Cell Biology·K M WeidnerW Birchmeier
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H TsudaS Hirohashi
Jan 1, 1990·Annual Review of Biochemistry·M Takeichi
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M OzawaR Kemler
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N PeyriérasF Jacob
May 1, 1989·Japanese Journal of Cancer Research : Gann·M HashimotoK Yokoro
Jan 1, 1989·The Plant Cell·J L BowmanE M Meyerowitz
Aug 1, 1989·Cancer Genetics and Cytogenetics·S Pathak, M K Dhaliwal
Jul 31, 1987·Biochemical and Biophysical Research Communications·D H WachsstockS Lin
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W J GallinB A Cunningham
Dec 1, 1994·The Journal of Cell Biology·J HülskenJ Behrens
Mar 1, 1994·British Journal of Cancer·M KatayamaI Kato
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·T OdaS Hirohashi

❮ Previous
Next ❯

Citations

Mar 25, 2006·Future Oncology·Caroline SalonElisabeth Brambilla
Mar 10, 1999·Journal of Clinical Pathology·J M ReteraP H Theunissen
Mar 1, 2000·Molecular Pathology : MP·I R Beavon
Oct 5, 2006·Journal of Clinical Pathology·David S P Tan, Stan Kaye
Nov 30, 2007·BMC Cancer·Marisa C L S GenelhuGeovanni D Cassali
Apr 9, 2008·World Journal of Gastroenterology : WJG·Yong-Quan ChuZhong-Sheng Zhao
Jul 9, 2008·World Journal of Gastroenterology : WJG·Adam ElzagheidSeppo Pyrhonen
Sep 17, 2008·Molecular and Cellular Biology·Yan-Nian LiuJi-Hshiung Chen
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Allison S HarneyThomas J Meade
Sep 29, 2009·American Journal of Physiology. Cell Physiology·Clint PerryIrina I Grichtchenko
Mar 9, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P DursunA Ayhan
May 4, 1999·The Journal of Cell Biology·S AonoM Takeichi
Dec 20, 2011·Cell Communication & Adhesion·Andrea Buda, Massimo Pignatelli
Jun 6, 2015·International Journal of Molecular Medicine·Dongdong MengGuijun Qin
Jan 16, 2007·Histopathology·R SormunenY Soini
Sep 14, 2015·Biological Research·Fabiana Greyce Oliveira AlmeidaMaria da Gloria da Costa Carvalho
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A I Rojas, A R Ahmed
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takeshi ShimamuraSetsuo Hirohashi
Oct 17, 2003·Clinics in Laboratory Medicine·Ben DavidsonAasmund Berner
Feb 12, 2008·Journal of Cancer Research and Clinical Oncology·Meiyan LiangMitsuomi Hirashima
Aug 28, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marisa C L S GenelhuGeovanni D Cassali
Dec 5, 1998·Microscopy Research and Technique·M A El-Bahrawy, M Pignatelli
Sep 11, 2004·Biochemical and Biophysical Research Communications·Hiroshi FukamachiYoshiaki Ito
Apr 22, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoon-La ChoiSeok Hyung Kim
Sep 17, 2002·International Journal of Surgical Pathology·Eleonora KarbovaJahn M Nesland
Jul 21, 2010·International Journal of Surgical Pathology·Morelva Toro de Méndez, Antonio Llombart Bosch
Dec 26, 2009·International Journal of Surgical Pathology·Chetana ChandrashekarRekha Krishnapillai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.