E-cadherin, N-cadherin Expression and Histologic Characterization of Canine Choroid Plexus Tumors

Veterinary Pathology
A ReginatoMaria Teresa Mandara

Abstract

Choroid plexus tumors (CPTs) are reported with an increasing incidence in dogs, and they call for a reexamination of histologic features and criteria of classification corresponding to their biological behavior. In this study, the human World Health Organization classification was applied to 16 canine CPTs, and the expression of molecules involved in neoplastic cell adhesion (E-cadherin, N-cadherin), invasion (doublecortin), and proliferation (Ki-67) was investigated. Mitotic index was found to be the main criterion for grading CPTs. Cell density and multilayering of papillae were also statistically associated with histologic grade. Intraventricular spread and parenchymal invasion was observed for tumors showing histologic benign features. E-cadherin was expressed in all CPT grades, independent of tumor invasion. N-cadherin immunolabeling was more expressed in grade I than high-grade CPTs, whereas doublecortin expression was not detected in CPTs. An increasing proliferative activity was observed in relation with histologic grade.

References

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Citations

Jul 4, 2019·Veterinary Pathology·Andrew D MillerF Yvonne Schulman
Jun 25, 2020·Veterinary Pathology·Serenella SilvestriChiara Brachelente
Mar 17, 2018·Journal of Neuropathology and Experimental Neurology·Devin AnconaPeter J Dickinson
May 8, 2020·Fluids and Barriers of the CNS·Peter SolárMarek Joukal
Oct 21, 2020·International Journal of Molecular Sciences·Ilona KaszakPiotr Jurka

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Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS

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