E-cigarettes can emit formaldehyde at high levels under conditions that have been reported to be non-averse to users

Scientific Reports
James C SalamancaRobert M Strongin

Abstract

E-cigarette aerosol emission studies typically focus on benchmarking toxicant levels versus those of cigarettes. However, such studies do not fully account for the distinct chemical makeup of e-liquids and their unique properties. These approaches often conclude that there are fewer and lower levels of toxins produced by e-cigarettes than by cigarettes. In 2015, we reported the discovery of new hemiacetals derived from the reaction of formaldehyde and the e-liquid solvents. The main finding was that they constituted a significant proportion of potentially undetected formaldehyde. Moreover, unlike gaseous formaldehyde, the hemiacetals reside in the aerosol particulate phase, and thus are capable of delivering formaldehyde more deeply into the lungs. However, the findings were criticized by those claiming that some of the results were obtained under conditions that are averse to vapers. A "reinvestigation" of our study was recently published addressing this latter issue. However, this reinvestigation ignored major details, including no mention of the formaldehyde hemiacetals. Herein, we isolated both gaseous formaldehyde and formaldehyde hemiacetals at an intermediate power level claimed, in the "reinvestigation", to be relevant ...Continue Reading

References

Jan 22, 2015·The New England Journal of Medicine·R Paul JensenDavid H Peyton
May 23, 2015·Addiction·Konstantinos E FarsalinosKonstantinos Poulas
Sep 27, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Temperance R Rowell, Robert Tarran
Jan 9, 2016·Regulatory Toxicology and Pharmacology : RTP·I G GillmanA R Paolantonio
Apr 15, 2016·MMWR. Morbidity and Mortality Weekly Report·Tushar SinghBrian A King
Feb 15, 2017·Scientific Reports·R Paul JensenDavid H Peyton
Apr 11, 2017·ACS Omega·Mumiye A OgunwaleXiao-An Fu
Jul 8, 2017·Chemical Research in Toxicology·Ahmad El-HellaniNajat A Saliba
Sep 3, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Konstantinos E FarsalinosKonstantinos Poulas
Sep 10, 2017·Scientific Reports·James C SalamancaRobert M Strongin
Nov 8, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Konstantinos E FarsalinosGene Gillman
Jan 1, 2017·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Mohammad BaassiriAlan Shihadeh

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Citations

Mar 9, 2019·Annual Review of Analytical Chemistry·Robert M Strongin
Sep 5, 2019·The Journal of Clinical Investigation·Matthew C MadisonFarrah Kheradmand
Jan 9, 2020·Annual Review of Public Health·Liqiao LiYifang Zhu
Jan 30, 2020·Chemistry : a European Journal·Ignacio ColomerRoberto Fernández de la Pradilla
May 5, 2020·Environmental Health Perspectives·Silke Schmidt
Jul 30, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kielan Darcy McAlindenSukhwinder Singh Sohal
Aug 9, 2018·Toxics·Vera SamburovaAndrey Khlystov
Aug 28, 2020·Expert Opinion on Drug Delivery·Vinit V GholapMatthew S Halquist
Oct 2, 2019·BMJ : British Medical Journal·Jeffrey E GottsRobert Tarran
Dec 16, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sairam V JabbaSven-Eric Jordt
Jul 10, 2019·Revue des maladies respiratoires·P Dupont, H-J Aubin
May 18, 2021·Cannabis and Cannabinoid Research·Alexandra M Ward, Jon O Ebbert
Jul 23, 2019·Chemical Research in Toxicology·Kelly R SmithNatalie R Gassman
Aug 14, 2020·Chemical Research in Toxicology·Rachel El-HageNajat Aoun Saliba
Dec 21, 2019·Chemical Research in Toxicology·Maxim BelushkinGuy Jaccard

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Methods Mentioned

BETA
NMR

Software Mentioned

MestreLab
Global Deconvolution

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