E. coli Cell Cycle Machinery

Sub-cellular Biochemistry
J Lutkenhaus, Shishen Du

Abstract

Cytokinesis in E. coli is organized by a cytoskeletal element designated the Z ring. The Z ring is formed at midcell by the coalescence of FtsZ filaments tethered to the membrane by interaction of FtsZ's conserved C-terminal peptide (CCTP) with two membrane-associated proteins, FtsA and ZipA. Although interaction between an FtsZ monomer and either of these proteins is of low affinity, high affinity is achieved through avidity - polymerization linked CCTPs interacting with the membrane tethers. The placement of the Z ring at midcell is ensured by antagonists of FtsZ polymerization that are positioned within the cell and target FtsZ filaments through the CCTP. The placement of the ring is reinforced by a protein network that extends from the terminus (Ter) region of the chromosome to the Z ring. Once the Z ring is established, additional proteins are recruited through interaction with FtsA, to form the divisome. The assembled divisome is then activated by FtsN to carry out septal peptidoglycan synthesis, with a dynamic Z ring serving as a guide for septum formation. As the septum forms, the cell wall is split by spatially regulated hydrolases and the outer membrane invaginates in step with the aid of a transenvelope complex to yi...Continue Reading

Citations

Feb 8, 2018·The Journal of Biological Chemistry·Kyung-Tae ParkJoe Lutkenhaus
Apr 4, 2018·The Journal of Biological Chemistry·Haiyan HuangYaodong Chen
Apr 25, 2018·Frontiers in Microbiology·Sue A FloresPamela J B Brown
Feb 25, 2020·Annual Review of Biophysics·Ryan McQuillen, Jie Xiao
Jul 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Sebastien PichoffJoe Lutkenhaus
Jan 30, 2019·Journal of Bacteriology·Bing LiuPiet A J de Boer

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