E. coli diversity: low in colorectal cancer.

BMC Medical Genomics
Le TangShu-Lin Liu


Escherichia coli are mostly commensals but also contain pathogenic lineages. It is largely unclear whether the commensal E. coli as the potential origins of pathogenic lineages may consist of monophyletic or polyphyletic populations, elucidation of which is expected to lead to novel insights into the associations of E. coli diversity with human health and diseases. Using genomic sequencing and pulsed field gel electrophoresis (PFGE) techniques, we analyzed E. coli from the intestinal microbiota of three groups of healthy individuals, including preschool children, university students, and seniors of a longevity village, as well as colorectal cancer (CRC) patients, to probe the commensal E. coli populations for their diversity. We delineated the 2280 fresh E. coli isolates from 185 subjects into distinct genome types (genotypes) by PFGE. The genomic diversity of the sampled E. coli populations was so high that a given subject may have multiple genotypes of E. coli, with the general diversity within a host going up from preschool children through university students to seniors. Compared to the healthy subjects, the CRC patients had the lowest diversity level among their E. coli isolates. Notably, E. coli isolates from CRC patients...Continue Reading


Mar 1, 1992·Journal of Bacteriology·S L Liu, K E Sanderson
Aug 11, 1987·Nucleic Acids Research·M McClellandM Nelson
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T S WhittamR K Selander
Feb 1, 1984·Journal of Bacteriology·H Ochman, R K Selander
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·H Ochman, R K Selander
Jun 1, 1995·Journal of Bacteriology·S L Liu, K E Sanderson
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S L LiuK E Sanderson
Apr 1, 1997·Journal of Molecular Evolution·J G Lawrence, H Ochman
Sep 5, 1997·Science·F R BlattnerY Shao
Feb 11, 1998·Clinical Microbiology Reviews·J P Nataro, J B Kaper
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·H OchmanN A Moran
Nov 5, 1999·Journal of Bacteriology·S L LiuR N Johnston
Nov 11, 1999·Nucleic Acids Research·A L DelcherS L Salzberg
May 24, 2000·The Journal of Infectious Diseases·T A Russo, J R Johnson
Sep 30, 2000·Applied and Environmental Microbiology·O ClermontE Bingen
Dec 7, 2000·The Journal of Infectious Diseases·J R JohnsonA L Stell
Feb 24, 2001·Nature·N T PernaF R Blattner
Apr 11, 2002·The Journal of Laboratory and Clinical Medicine·James R Johnson, Thomas A Russo
Jul 26, 2002·Molecular Biology and Evolution·Alex Mira, Howard Ochman
Aug 29, 2002·The Journal of Infectious Diseases·James R Johnson, Thomas A Russo
Dec 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·R A WelchF R Blattner
Mar 20, 2003·Journal of Bacteriology·Wen DengFrederick R Blattner
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Claire KidgellMark Achtman
Mar 26, 2004·Nature Reviews. Microbiology·James B KaperHarry L Mobley
Oct 21, 2005·Molecular Biology and Evolution·Gui-Rong LiuShu-Lin Liu
Oct 22, 2005·International Journal of Medical Microbiology : IJMM·James R Johnson, Thomas A Russo
Jan 7, 2006·Nucleic Acids Research·Monica RileyBarry L Wanner
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Swaine L ChenJeffrey I Gordon
Jan 24, 2007·Bioinformatics·Arthur L DelcherSteven L Salzberg
Mar 22, 2008·Genome Génome / Conseil National De Recherches Canada·Pradeep Reddy Marri, G Brian Golding
Mar 28, 2008·Methods in Molecular Biology·Shu-Lin Liu
Oct 22, 2008·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Kenshiro OshimaMasahira Hattori

❮ Previous
Next ❯


Aug 29, 2020·Expert Review of Anti-infective Therapy·Juraj BosákDavid Šmajs
Nov 9, 2021·Clinical & Experimental Metastasis·Charlotte HenstraAnika Nagelkerke

❮ Previous
Next ❯

Methods Mentioned

cleavage profiling

Software Mentioned

GraphPad Prism
Perl scripts

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.