E-mail management of the modified Atkins Diet for adults with epilepsy is feasible and effective

Epilepsia
Mackenzie C CervenkaEric H Kossoff

Abstract

The modified Atkins Diet (MAD) is an effective dietary treatment for children with epilepsy. However, adults may have limited access to this therapy because of lack of availability of dietitian or nutrition support or familiarity with the diet by their treating neurologist. This study was designed to investigate the tolerability and efficacy of the MAD administered solely via e-mail to adults with pharmacoresistant epilepsy. A prospective, open-label, proof-of-principle 3-month study design was employed. Adults were enrolled, instructed on how to self-administer a 20 g carbohydrate per day MAD, and followed by the investigators only via e-mail. There were no clinic visits or dietitian contacts during the study period. Twenty-five participants (median age 30 years [range 18-66 years], 68% female) consented and 22 started the MAD. The median prior anticonvulsants was 5 (range 2-10) and seizure frequency was 5 per week (range 1-140). Urinary ketosis was achieved in 21 participants (95%), of which 16 (76%) reported at least 40 mg/dl (moderate). Twenty-one participants (95%) remained on the MAD at 1 month and 14 (64%) at 3 months. After 1 month, 9 (41%) had >50% seizure reduction including one (5%) with >90% seizure reduction using ...Continue Reading

Associated Clinical Trials

References

Jan 20, 2004·Journal of Telemedicine and Telecare·Victor PattersonRichard Chua
Oct 9, 2007·Epilepsia·Eric H KossoffEileen P G Vining
Jun 24, 2008·Clinical Neurology and Neurosurgery·Evelien CarrettePaul Boon
Dec 17, 2008·Epilepsia·Eric H Kossoff, Jennifer L Dorward
Oct 17, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S Nizam AhmedWarren Boling
Oct 13, 2010·Epilepsy & Behavior : E&B·Pavel KleinRandi Weissberger

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Citations

Apr 6, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·J Helen CrossLieven Lagae
Jun 7, 2013·Continuum : Lifelong Learning in Neurology·Mackenzie C Cervenka, Eric H Kossoff
Nov 11, 2014·Nutritional Neuroscience·Mackenzie C CervenkaEric H Kossoff
Apr 10, 2016·Epilepsy & Behavior : E&B·Mackenzie C CervenkaEric H Kossoff
Jul 23, 2015·Epilepsia·Elizabeth A Felton, Mackenzie C Cervenka
Jan 5, 2014·Epilepsy & Behavior : E&B·Eric H KossoffZahava Turner
Oct 21, 2016·Arquivos de neuro-psiquiatria·Letícia Pereira de Brito Sampaio
May 15, 2013·Journal of Child Neurology·Mackenzie C CervenkaJeff S Volek
Dec 9, 2017·Epilepsy Currents·Tanya J W McDonald, Mackenzie C Cervenka
Mar 13, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K J Martin-McGillUNKNOWN Ketogenic Dietitians Research Network (KDRN)
Dec 4, 2019·Epilepsy Currents·Eric Kossoff, Mackenzie Cervenka
Sep 19, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tanya J W McDonald, Mackenzie C Cervenka
Feb 15, 2019·Frontiers in Neuroscience·Isabella D'Andrea MeiraPriscila Oliveira da Conceição
Aug 12, 2018·Brain Sciences·Tanya J W McDonald, Mackenzie C Cervenka
Dec 10, 2020·Arquivos de neuro-psiquiatria·Renan Barros DominguesRicardo Nitrini
Feb 7, 2021·Pediatric Neurology·Erin Fedak Romanowski, Abate Yeshidinber Weldetsadik
Nov 7, 2020·Seminars in Neurology·Tanya J W McDonald, Mackenzie C Cervenka
Mar 22, 2020·Epilepsy Research·Khalil S Husari, Mackenzie C Cervenka
Jun 9, 2020·Epilepsy & Behavior : E&B·Eric H KossoffMackenzie C Cervenka

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