E-NTPDases in human airways: Regulation and relevance for chronic lung diseases.

Purinergic Signalling
Lauranell H Burch, Maryse Picher

Abstract

Chronic obstructive lung diseases are characterized by the inability to prevent bacterial infection and a gradual loss of lung function caused by recurrent inflammatory responses. In the past decade, numerous studies have demonstrated the importance of nucleotide-mediated bacterial clearance. Their interaction with P2 receptors on airway epithelia provides a rapid 'on-and-off' signal stimulating mucus secretion, cilia beating activity and surface hydration. On the other hand, abnormally high ATP levels resulting from damaged epithelia and bacterial lysis may cause lung edema and exacerbate inflammatory responses. Airway ATP concentrations are regulated by ecto nucleoside triphosphate diphosphohydrolases (E-NTPDases) which are expressed on the mucosal surface and catalyze the sequential dephosphorylation of nucleoside triphosphates to nucleoside monophosphates (ATP --> ADP --> AMP). The common bacterial product, Pseudomonas aeruginosa lipopolysaccharide (LPS), induces an acute reduction in azide-sensitive E-NTPDase activities, followed by a sustained increase in activity as well as NTPDase 1 and NTPDase 3 expression. Accordingly, chronic lung diseases, including cystic fibrosis (CF) and primary ciliary dyskinesia, are characteri...Continue Reading

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Citations

May 5, 2012·Purinergic Signalling·Herbert ZimmermannNorbert Sträter
Jul 30, 2014·Molecular and Cellular Biochemistry·Fátima Husein AbdallaCinthia Melazzo Andrade Mazzanti
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Jul 8, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Llilian Arzola-MartínezManuel J Villalón

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Methods Mentioned

BETA
bronchoalveolar
lavage
PCR

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