PMID: 6981201Apr 1, 1982Paper

E receptor expression of T lymphocytes in T lymphoproliferative diseases

Scandinavian Journal of Haematology
V JønssonK Thomsen

Abstract

The lymphoid component of skin infiltrates from 6 cases of mycosis fungoides and 2 cases of T cell chronic lymphatic leukaemia consisted almost exclusively of T lymphocytes with abnormally high E receptor expression. Such T cells were also found to dominate the skin infiltrates from 10 patients with severe atopic dermatitis. Blood T lymphocyte counts from all types of patients were within the normal range, but even the blood T lymphocytes of the patients had a strong E receptor expression. The bone marrow in atopic dermatitis and in mycosis fungoides showed normal T cell counts with normal E receptor expression. Supported by basic lymphocyte-kinetic considerations it is likely that the skin in T lymphoproliferative diseases is characterized by an abnormal ability to home and/or to trap T lymphocytes with strong E receptor expression.

References

May 1, 1979·The British Journal of Dermatology·N A Byrom, D M Timlin
May 1, 1979·The British Journal of Dermatology·N A ByromJ R Hobbs
May 1, 1979·The British Journal of Dermatology·L R BraathenT Eeg-Larsen
Sep 1, 1976·The Journal of Investigative Dermatology·R L Edelson
Jan 1, 1976·Journal of Immunological Methods·A SaxonR A Robins
Feb 1, 1981·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V Jønsson, G Klein
Jul 10, 1980·The New England Journal of Medicine·R A MillerI R McDougall
Dec 1, 1971·European Journal of Immunology·F P SiegalH G Kunkel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.