E-selectin expression in experimental models of inflammation in mice

The Journal of Pathology
U HenseleitC Sunderkötter

Abstract

E-selectin (CD62E, formerly termed ELAM-1) is a cytokine-inducible adhesion molecule which mediates the binding of neutrophils, monocytes, and skin homing T-cells. The murine homologue of E-selectin has been cloned. A monoclonal antibody (21KC10) was used here to study immunohistochemically the expression and regulation of murine E-selectin in vitro and in vivo. As described for the human system, there was no staining of normal endothelium in skin and other tissues. LPS and tumour necrosis factor-alpha (TNF-alpha), but not interleukin-4 (IL-4) or interferon-gamma (IFN-gamma), induced a transient expression of E-selectin, both when injected in vivo and when added to endothelial cell lines in vitro. To analyse temporal expression of E-selectin under pathophysiological conditions in vivo, we chose two murine models of inflammation: allergic (ACD) and irritant contact dermatitis (ICD). Expression of E-selectin was found to be induced on vascular endothelium of post-capillary venules in both ACD and ICD. In ICD, maximal staining of endothelial cells occurred earlier than in ACD. Expression of E-selectin during ICD and ACD was then compared between strains of mice which differ with regard to the intensity of their inflammatory reacti...Continue Reading

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Citations

Dec 12, 2001·Experimental Dermatology·C SunderkötterG Kolde
Jun 5, 2008·Inflammatory Bowel Diseases·Jesús Rivera-NievesKlaus Ley
Sep 1, 1999·The Journal of Investigative Dermatology·N A KukutschP von den Driesch
Oct 29, 2011·Blood·Debanjan SarkarJeffrey M Karp
Oct 3, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Latasha D AbeynaikeMichael J Hickey
Dec 18, 2001·American Journal of Physiology. Cell Physiology·Elaine A LidingtonJustin C Mason
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M YinR G Thurman
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura PiccioGabriela Constantin
Mar 21, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hiroaki KabashimaTadahiko Iijima
May 18, 1999·Seminars in Immunology·A A KulidjianT B Issekutz

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