E-selectin involvement in the pathogenesis of splanchnic artery occlusion shock

European Journal of Pharmacology
D AltavillaA P Caputi

Abstract

We investigated the involvement of E-selectin in the pathogenesis of splanchnic artery occlusion shock. Splanchnic artery occlusion shock was induced in anaesthetized rats by clamping splanchnic arteries for 45 min. Sham-operated animals were used as controls. Survival time, serum tumor necrosis factor-alpha, while blood cell count, mean arterial blood pressure and myeloperoxidase activity were determined. Splanchnic artery occlusion-shocked rats had a decreased survival time (85 +/- 8 min, while sham-shocked rats survived more than 4 h), reduced mean arterial blood pressure, increased serum levels of tumor necrosis factor-alpha (186 +/- 9 U/ml) and myeloperoxidase activity in the ileum (0.10 +/- 0.04 U x 10(-3)/g tissue) and in the lung (1.5 +/- 0.06 U x 10(-3)/g tissue). Shocked rats showed histological alterations in the ileum and in the lung. Administration of a hyperimmune serum containing specific antibodies raised against E-selectin significantly increased survival time (225 +/- 10 min), reduced leukopenia and myeloperoxidase activity both in the ileum (0.035 +/- 0.001 U x 10(-3)/g tissue) and in the lung (0.3 +/- 0.005 U x 10(-3)/g tissue), improved the cardiovascular changes and reduced the histological alterations in ...Continue Reading

References

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Citations

Aug 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D AltavillaA P Caputi
Mar 17, 2004·Burns : Journal of the International Society for Burn Injuries·Mübin HoşnuterAhmet Işikdemir
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shawn D St PeterDavid C Mulligan
Nov 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Majid AliKeith E Norman

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