PMID: 3748461Aug 4, 1986Paper

E-type prostaglandins depolarize primary afferent neurons of the neonatal rat

Neuroscience Letters
M YanagisawaJ E García-Arrarás

Abstract

The mechanism of action of prostaglandins (PGs) to sensitize sensory terminals to noxious stimuli was studied in the isolated spinal cord-tail preparation of the newborn rat. Application of a small amount of capsaicin to the tail induced a nociceptive reflex that was recorded extracellularly from the lumbar ventral root. Pretreatment of the tail with PGE1 or E2 (0.8-4 microM) markedly potentiated the capsaicin-induced nociceptive reflex. In the isolated spinal cord preparation of the newborn rat, application of PGE1 or E2 (10 nM-1 microM) induced a depolarization of the dorsal root. Based on these results we propose a hypothesis that PGs regulate the resting potential of the peripheral terminals of nociceptive primary afferent fibers and that the depolarization is associated with lowering of threshold for various noxious stimuli.

References

May 23, 1985·Neuroscience Letters·J D LeahP J Snow
Nov 13, 1984·European Journal of Pharmacology·M YanagisawaM Otsuka
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P I Baccaglini, P G Hogan
Mar 17, 1982·Neuroscience Letters·P Kenins
Aug 1, 1953·Journal of Cellular Physiology·H P JENERICK, R W GERARD

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Citations

Aug 2, 1988·European Journal of Pharmacology·C A MaggiA Meli
Oct 8, 1986·Neuroscience Letters·M YanagisawaN Yanaihara
Jun 5, 1998·Trends in Pharmacological Sciences·K R BleyJ A Smith
Mar 29, 2001·Progress in Neurobiology·H Vanegas, H G Schaible
Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
Jun 10, 2014·Developmental Psychobiology·Gordon A Barr, Deirtra A Hunter
Apr 8, 1998·The American Journal of Physiology·L J Jennings, G M Mawe
Dec 31, 1997·The American Journal of Physiology·A GarlandJ Solway
Aug 15, 1992·The Journal of Comparative Neurology·C D BrederC B Saper

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